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Academic Literature

Gonçalves A, Griffiths LG, Anthony RV, Orton EC. Decellularization of bovine pericardium for tissue-engineering by targeted removal of xenoantigens. J Heart Valve Dis 14:212-217, 2005. View Abstract.

Disatian S, Ehrhart EJ, Zimmerman S, Orton EC. Interstitial cells from dogs with naturally-occurring myxomatous mitral valve disease undergo phenotype transformation. J Heart Valve Dis 17:402-412, 2008. View Abstract.

Griffiths LG, Chloe L, Lee KH, Reardon KF, Orton EC. Protein extraction and two-dimensional gel electrophoresis of water- and lipid-soluble proteins from bovine pericardium: a low cellularity tissue. Electrophoresis 29: 4508-4515, 2008. View Abstract.

Griffiths LG, Chloe L, Reardon KF, Dow SW, Orton EC. Immunoproteomic identification of bovine pericardium xenoantigens. Biomaterials 29:3514-3520, 2008. View Abstract.

Arai S, Orton EC. Immunoblot detection of soluble protein antigens from sodium dodecyl sulfate- and sodium deoxycholate-treated candidate bioscaffold tissues. J Heart Valve Dis 18:439-443, 2009. View Abstract.

Caamaño S, Arai S, Strauss SH, Orton EC. Does sodium dodecyl sulfate wash out of detergent-treated bovine pericardium at cytotoxic concentrations? J Heart Valve Dis 18:101-105, 2009. View Abstract.

Disatian S, Orton EC. Autocrine serotonin and transforming growth factor beta 1 signaling mediates spontaneous myxomatous mitral valve disease. J Heart Valve Dis 18:44-51, 2009. View Abstract.

Lacerda CMR, Disatian S, Orton EC. Differential protein expression between normal, early-stage, and late-stage myxomatous mitral valves from dogs. Proteomics – Clinical Applications 3:1422-1429, 2009. View Abstract.

Arai S, Lacerda CMR, Orton EC. Tissue-gel electrophoresis enhances antigen removal from porcine aortic valve and bovine pericardium. J Heart Valve Dis 19:753-758, 2010. View Abstract.

Disatian S, Lacerda C, Orton EC. Tryptophan hydroxylase 1 expression is increased on phenotype-altered canine and human degenerative myxomatous mitral valves. J Heart Valve Dis 19:71-78, 2010. View Abstract.

Scruggs SM, Disatian S, Orton EC. Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease. J Vet Cardiol 12:163-169, 2010. View Abstract.

Lacerda CMR, Kisiday J, Johnson B, Orton EC. Local serotoinin mediates tensile strain-induced phenotype transformation and matrix alteration in cultured mitral valves. Am J Physiol: Heart & Circ 302:H1983-H1990, 2012.

Lacerda CMR, MacLea H, Kisiday J, Orton EC. Static and cyclic tensile strain induce serotonin and myxomatous effector proteins in canine mitral valves. J Vet Cardiol 14:223-230, 2012.

Lacerda CMR, Orton EC. Evidence of a role for tensile loading in the pathogenesis of mitral valve degeneration. J Clin Experi Cardiol, 2012. doi:10.4172/2155-9880.S3-004

Orton, EC, Lacerda CMR, MacLea HB. Signaling pathways in mitral valve degeneration. J Vet Cardiol 14:7-17, 2012.

Orton, EC. Mitral valve degeneration: Still more questions than answers. J Vet Cardiol 14:3-5, 2012.

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