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Clinical Trials

For Small Animals

Oncology

Flint Animal Cancer Center

Who Qualifies:

Your pet may be eligible for one or more of our clinical trials, depending on the diagnosis and overall health of your animal. Your oncology veterinarian will discuss all standard treatment options with you. They will also offer you the opportunity to participate in clinical trials if appropriate, or to consult with the clinical trial coordinator to learn more.

More Information:

The oncology service runs many ongoing clinical trials for multiple different cancer types at any one time. Please view our available oncology clinical trials program to learn more about the studies that are currently enrolling patients.

To Enroll:

If you have further questions about any of our clinical trials, Please either login or sign up to submit a consulting form or call or Oncology Clinical Coordinator at (970) 297-4068.

Available Clinical Trials

Online Consulting Form


Small Animal Sports Medicine

Who Qualifies: 

If your pet has been diagnosed with a rupture of the cranial cruciate ligament and you would like to pursue surgical fixation with a tibial plateau leveling osteotomy (TPLO), you may want to consider this study.

More Information:

As you may know, the TPLO procedure involves creating a bone fracture which subsequently needs to heal prior to your pet being able to resume normal activity. Hence, enhancement of bone healing is desirable to speed up the recovery after this procedure. Please visit the Small Animal Sports Medicine page to read more.

To Enroll:

Email CanineRehab@colostate.edu


Cardiology

Transapical Mitral Valve Replacement for Dogs: Early Feasibility Study

Who Qualifies:

Dogs with naturally-occurring, end-stage, medically-refractory (stage D), degenerative mitral regurgitation that are between 8 and 18 kgs. and do not have other serious non-cardiac disease.

More Information:

This is an early feasibility clinical trial of a novel, minimally invasive beating heart mitral replacement surgery in dogs affected with severe degenerative mitral valve disease. Please see the TAMVR Information Sheet for more information.

View a video explaining the MitralSeal Canine Mitral Valve Replacement Technology​.

To Enroll:

E-mail Tracy Webb


Efficacy of Ranolazine for Preventing Relapse of Atrial Fibrillation in Dogs with Heart Disease

Who Qualifies:

The study is open to client-owned dogs with spontaneous, sustained atrial fibrillation and structural heart disease (either congenital or acquired).

More Information:

Heart disease and atrial fibrillation are common in dogs, and co-existence of these conditions is associated with a very poor prognosis. It is not surprising, therefore, that restoration of normal (sinus) rhythm stabilizes the clinical status in >80% of dogs. This study is a placebo controlled clinical trial to determine whether ranolazine, an FDA approved drug to treat ischemic cardiac pain in people, given in addition to the traditional antiarrhythmic agent, amiodarone, is superior to amiodarone for maintaining normal (sinus) heart rhythm after cardioversion from atrial fibrillation. Ranoloazine has potent anti- atrial fibrillation effects and has been shown in K9 heart failure models to improve cardiac function.

Read more about the Efficacy of Ranolazine for Preventing Relapse of Atrial Fibrillation in Dogs with Heart Disease clinical trial.

To Enroll:

Contact Dr. Bright and Dr. Ames at (970) 297-5000


Internal Medicine

Investigation of Gastrointestinal Motility in Dogs Undergoing a Prophylactic Gastropexy

Who Qualifies:

Your dog should weigh at least 40 kg to be a candidate for prophylactic laparoscopic gastropexy. He or she must exclusively be fed the dispensed Purina E/N dry dog food until the end of the study.

More Information:

The purpose of this study is to evaluate gastrointestinal motility following prophylactic (preventative) laparoscopic gastropexy. This study requires a minimally invasive surgery, administration of a SmartPill, and
feeding of a standardized diet. For more information, please read the "Investigation of Gastrointestinal Motility in Dogs Undergoing a Prophylactic Gastropexy" client consent form.

To Enroll:

Contact Dr. Eric Monnet or Dr. Kristin Coleman at (970) 297-5000


Mesenchymal Stem Cell Therapy for Canine Chronic Hepatitis

Who Qualifies:

  1. Dogs suspected to have chronic hepatitis and needing a liver biopsy to confirm the diagnosis
  2. Dogs who have already been diagnosed with chronic hepatitis and either (a) have not yet been started on immunosuppressive medications, or (b) are failing standard of care therapies

More Information:

To learn more about this study, read the article "Vets Study Stem-Cell Therapy for Chronic Hepatitis."

To Enroll:

E-mail Dr. Bradley


Chronic Hepatitis in Standard Poodles

Who Qualifies:

Any standard poodle suspected or confirmed to have chronic hepatitis

More information:

If a liver biopsy is planned, the study will cover the cost of the pathologist's analysis, including special stains and quantitative metal levels. Please see the client information sheet for additional details.

To Enroll:


Feline Hairball Study

Who Qualifies:

Any cat that produces hairballs.

More Information:

Cats will receive a free checkup and blood work (Texas A+M GI panel). We ask that the owner provides a fresh, wet hairball placed in a plastic ziplock bag and stored in the fridge.

To Enroll:

E-mail Dr. Webb


A Novel Treatment for Feline Diabetes Mellitus

Who Qualifies:

Any cat that has been diagnosed with diabetes.

More Information:

This study will determine if Superoxide Dismutase (SOD) aids cats with Diabetes. Cats will receive a free checkups and blood work pre- and post-treatment. This is a double-blind study and there is the possibility of your cat receiving placebo; however, it is possible to receive SOD treatment post-study.

To Enroll:

E-mail Dr. Webb


Urine Culture Techniques Study

Who Qualifies:

You have been offered to participate in this study if your pet is suspected of having pyelonephritis, has a simple urinary tract infection, has kidney disease, or is healthy. We need animals in all categories to demonstrate that the blood culture bottles are not only better than standard culture methods, but that they are at least as good.

More Information:

We are testing a potentially more sensitive way to culture urine so that we can detect infections that do not appear on regular cultures.  We will place a small sample of urine in a special bottle normally used to culture bacteria in the bloodstream where there are very few numbers of organisms.  These are called blood culture bottles. We are hoping that we can detect more cases of pyelonephritis with this technique. For more information, view the Urine Culture Techniques Study client consent form.

To Enroll:

E-mail Dr. Quimby


Evaluation of Gastroesophageal Reflux in Dogs with Laryngeal Paralysis

Who Qualifies:

Dogs diagnosed with laryngeal paralysis.

More Information:

The incidence of gastroesophageal reflux is not known in dogs with laryngeal paralysis. It may contribute to the development of aspiration pneumonia with laryngeal paralysis. To document the frequency and the severity of gastroesophageal reflux, a nasoesophageal probe will be placed in dogs diagnosed with laryngeal paralysis to measure esophageal pH before and after surgery. Data will be collected continuously for 24 hours. Patients involved in the study will receive $350 to cover surgery fees. All the other expenses related to the research will be covered.

Contact Information:

Call Dr. K. Tarvin, Dr. E. Monnet, or Geri Baker; (970) 297-5000 


Ophthalmology

The Effects of Topical Naltrexone on Corneal Sensitivity and Tear Production in Diabetic Dogs

Who Qualifies:

All dogs must be confirmed diabetics based on previous history and blood work (documented glucosuria and blood glucose ≥200mg/dl) and have received insulin therapy for diabetes mellitus for at least two months prior to entering the study. Exclusion criteria include brachycephalic breed (pugs, bulldogs, boxers, etc.), significant systemic disease other than diabetes mellitus, pregnant or lactating, Schirmer tear test less than 5 mm wetting per minute, current treatment with topical ophthalmic medication, any current ocular disease requiring treatment.

More Information:

Our intent is to demonstrate the effectiveness of topically applied naltrexone in increasing the corneal sensitivity, tear production and tear film break up time in diabetic dogs. If this response can be documented, topical naltrexone could be used to improve the quality of vision and decrease suffering due to corneal disease in diabetic dogs.

To Enroll:

Email Dr. Trevor Arnold at tsarnold@colostate.edu.


For Equine

Equine Medicine & Surgery

Serum Venom and Antibody Concentrations in Rattlesnakes: Envenomated Horse Treatment with a Plasma Product That Contains Anti-Venom Antibodies 

Who Qualifies:

Horses that suffer a rattlesnake bite.

Study Details: 

The purpose of this study is to determine whether an equine plasma product (MG Biologics®) is effective at reducing the level of snake venom in the blood of a horse that has been bitten by a rattler. Enrolled horses will receive a 100 mL plasma product, saving $250.00 per dose.

All enrolled horses will receive 100 mL RLTLR equine plasma and will have a temporary catheter placement. 4 mL of blood will be obtained prior to administration of plasma, and 4 mL of blood will be obtained 1 hour after plasma. Lastly, 4 mL of blood will be obtained 24 hours after plasma administration. Blood will be analyzed for snake venom concentrations.

Contact Information:

Please email Jenifer.Gold@colostate.edu or Diana.Hassel@colostate.edu


Determining the Effectiveness of a New Anti-Inflammatory Agent on Clinical Characteristics of Horses with Severe Gastrointestinal Disease

Who Qualifies:

Adult horses (>1 year old) with surgical disease of the gastrointestinal tract or diarrhea.

More Information:

The purpose of this study is to characterize the efficacy of phenylmethimazole, a novel and potent anti-inflammatory agent, in reducing signs of endotoxemia and inflammation (high heart rate, pain, reddened mucous membranes, fever) in horses with severe colic or colitis (diarrhea).

Contact Information:

Call Dr. Diana Hassel at (970) 297-4271

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Contact Us:
Colorado State University
Veterinary Teaching Hospital
300 West Drake Road
Fort Collins, Colorado, 80523

Phone:
(970) 297-5000

Fax:
(970) 297-1205