Significance: Dogs and humans with mitral valve disease share the same cellular mechanisms.
Significance: This finding explains the connection between drugs that alter serotonin (appetite suppressants, antidepressive drugs, anti-migraine drugs) and heart valve disease. This research may help in the development of novel treatments that could be used to slow progression or prevent mitral valve disease.
Significance: New scaffold tissues may lead to the development of a "living" heart valve prosthesis that would solve many of the shortcomings of current heart valve prostheses.
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