The Dow Laboratory for Immunotherapy studies the role of the innate immune system in cancer and infectious diseases and works on development of new immunotherapeutic approaches to treat these diseases. Currently the laboratory is investigating the role of myeloid cells in regulating tumor growth and how manipulating these cells can impact cancer treatment. Other members of the cancer group are studying immune checkpoint molecules and how these molecules can be targeted for cancer immunotherapy. The laboratory also investigates the immunological properties of mesenchymal stem cells and how these cells can be used to suppress inflammation in chronic kidney and liver disease and to suppress chronic bacterial infections.
Current Research and Clinical Projects
Monocyte targeted immune therapy for cancer.
Regulation of early vaccine immunity by myeloid cell responses.
Checkpoint inhibitor targeted immunotherapy for cancer.
Immune suppressive mechanisms of mesenchymal stem cells.
Stem cell therapy for feline kidney disease and canine liver disease.
Anti-infective properties of activated mesenchymal stem cells.