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Rushika Perera

Dr. ​Rushika Perera; Assistant Professor or RNA Virology, Microbiology, Immunology, and Pathology

Dr. Rushika Perera





Dr. ​Rushika Perera
114 AIDL
Microbiology, Immunology, and Pathology
College of Veterinary Medicine and Biomedical Sciences
Colorado State University
Phone: (970) 491-8611


B.A., Goshen College, 1995
Ph.D., Purdue University, 2002

Current Academic Appointment

2013 - Present; Assistant Professor of RNA Virology, Colorado State University, Fort Collins, CO

Previous Academic Appointments

2005 - 2013; Assistant Research Scientist, Purdue University, West Lafayette, IN
2002 - 2005; Postdoctoral Fellow, University of California, Irvine, CA
1995 - 2002; Ph.D. Biological Sciences, Purdue University, West Lafayette, IN
1991 - 1995; B.A. Biology / B.A. Chemistry, Goshen College, Goshen, IN

Peer Review

Journal of Virology, PLoS Pathogens, PLoS One
Associate Member, F1000 Biology

Professional Associations

American Society for Virology, 1996 - Present


For the most current list of Dr. Rushika Perera's publications, please visit her PubMed page.

  1. Juhnjon J, Pennington, JG, Edwards TJ, Perera R, Lanman J and Richard J. Kuhn. (2014). Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells. Journal of Virology. 88(9):4687-97. PMCID: PMC3993787
  2. Plevka P, Lim PY, Perera R, Cardosa J, Suksatu A, Kuhn RJ, Rossmann MG. (2014). Neutralizing antibodies can initiate genome release from human enterovirus 71. Proc Natl Acad Sci USA. Jan 27. [Epub ahead of print] PMID: 24469789
  3. Plevka P, Perera R, Yap ML, Cardosa J, Kuhn RJ, Rossmann MG. (2013). Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. Proc Natl Acad Sci USA. Apr 2;110(14):5463-7. PMCID: PMC3619292
  4. *Perera, R., Riley, C., Hopf-Jannasch AS, Mezengie, G. I., A., Metz, T. O., Moore, R., Weitz, K. W., Pasa-Tolic, L., Adamec, J., & Kuhn, R.J. (2012). Dengue virus perturbs lipid metabolism in infected mosquito cells. PLoS Pathogens. 8(3):e1002584. PMCID: PMC3310792 
  5. Snyder, J., Berrios C. J., Edwards T. J., Jose, J., Perera, R. and Kuhn, R.J. (2012). Probing the early temporal and spatial interaction of the Sindbis virus capsid and E2 proteins with reverse genetics. Journal of Virology. 86(22):12372-83. PMCID: PMC3486501
  6. Plevka P., Perera R., Cardosa J., Kuhn R.J. and Rossmann M.R. (2012). Structure determination of enterovirus 71. Acta Crystallogr D Biol Crystallogr. Sep;68(Pt 9):1217-22. PMCID: PMC3489104
  7. Plevka P., Perera R., Cardosa J., Kuhn R.J. and Rossmann M.R. (2012). Crystal structure of human enterovirus 71. Science Jun 8;336(6086):1274. PMCID: PMC3448362
  8. Jose, J., Przybyla, L., Edwards, T. J., Perera, R., Burgner, J. W., & Kuhn, R. J. (2011). Interactions of the cytoplasmid domain of Sindbis virus E2 with nucleocapsid cores promote alphavirus budding. Journal of Virology. 86(5):2585-99. PMCID: PMC3302261
  9. Khadka, S., Vangeloff, A. D., Zhang, C., Siddavantam, P., Heaton, N., Sengupta, R., Hughes, R.E., Bell, R., Sahasrabudhe, S., Randall, G., Gribskov, M., Kuhn, R.J., Perera, R., & Lacount, D.J. (2011). A physical interaction network of dengue virus and human proteins. Molecular and Cellular Proteomics 10(12):M111.012187. PMCID: PMC3237087
  10. *Heaton, N. S., Perera, R., Berger, K. L., Khadka, S., Lacount, D. J., Kuhn, R. J. & Randall, G. (2010). Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl Acad Sci USA 107, 17345-17350. PMCID: PMC2951450
  11. Junjhon, J., Edwards, T. J., Utaipat, U., Bowman, V.D., Holdaway, H.A., Zhang, W., Keelapang, P., Puttikhunt, C., Perera R., Chipman, P.R., Kasinrerk, W., Malasit, P., Kuhn R.J. & Sittisombut, N. (2010). Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles. Journal of Virology 84, 8353-8358. PMCID: PMC2916513
  12. Bhattacharya, D., Mayuri, Best, S. M., Perera, R., Kuhn, R. J. & Striker, R. (2009). Protein kinase G phosphorylates mosquito-borne flavivirus NS5. Journal of Virology 83, 9195-9205. PMCID: PMC2738234
  13. Perera, R. & Kuhn, R. J. (2008). Structural proteomics of dengue virus. Current Opinions in Microbiol 11,  369-377. Review. PMCID: PMC2581888
  14. Perera, R., Khaliq, M. & Kuhn, R. J. (2008). Closing the door on flaviviruses: entry as a target for antiviral drug design. Antiviral Research 80, 11-22. Review. PMCID: PMC2646114
  15. Chang, W. S., Shang, H., Perera, R. M., Lok, S. M., Sedlak, D., Kuhn, R. J. & Lee, G. U. (2008). Rapid detection of dengue virus in serum using magnetic separation and fluorescence detection. Analyst 133, 233-240. PMID: 18227947
  16. Hong, E. M., Perera, R. & Kuhn, R. J. (2006). Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly. Journal of Virology 80, 8848-8855. PMCID: PMC1563918
  17. **Perera, R., Daijogo, S., Walter, B. L., Nguyen, J. H. & Semler, B. L. (2007). Cellular protein modification by poliovirus: the two faces of poly(rC)-binding protein. Journal of Virology 81, 8919-8932. PMCID: PMC1951425
  18. Cornell, C. T., Perera, R., Brunner, J. E. & Semler, B. L. (2004). Strand-specific RNA synthesis determinants in the RNA-dependent RNA polymerase of poliovirus. Journal of Virology 78, 4397-4407. PMCID: PMC387695
  19. Menon, E. L., Perera, R., Navarro, M., Kuhn, R. J. & Morrison, H. (2004). Phototoxicity against tumor cells and Sindbis virus by an octahedral rhodium bisbipyridyl complex and evidence for the genome as a target in viral photoinactivation. Inorganic Chemistry 43, 5373-5381. PMID: 15310216
  20. Menon, E. L., Perera, R., Kuhn, R. J. & Morrison, H. (2003). Reactive oxygen species formation by UV-A irradiation of urocanic acid and the role of trace metals in this chemistry. Photochem Photobiol 78, 567-575. PMID: 14743864
  21. Perera, R., Navaratnarajah, C. & Kuhn, R. J. (2003). A heterologous coiled coil can substitute for helix I of the Sindbis virus capsid protein. Journal of Virology 77, 8345-8353. PMCID: PMC165231
  22. Tellinghuisen, T. L., Perera, R. & Kuhn, R. J. (2001b). Genetic and biochemical studies on the assembly of an enveloped virus. Genet Eng (NY) 23, 83-112. Review. PMID: 11570108
  23. Tellinghuisen, T. L., Perera, R. & Kuhn, R. J. (2001a). In vitro assembly of Sindbis virus core-like particles from cross-linked dimers of truncated and mutant capsid proteins. Journal of Virology 75, 2810-2817. PMCID: PMC115906
  24. Perera, R., Owen, K. E., Tellinghuisen, T. L., Gorbalenya, A. E. & Kuhn, R. J. (2001). Alphavirus nucleocapsid protein contains a putative coiled coil alpha-helix important for core assembly. Journal of Virology 75, 1-10. PMCID: PMC113891
  25. Houghtaling, M. A., Perera, R., Owen, K. E., Wagner, S., Kuhn, R. J. & Morrison, H. (2000). Photobiological properties of positively charged methylene violet analogs. Photochem Photobiol 71, 20-28. PMID: 10649885
* Highlighted as an article of significant interest by the journal
** Selected by Faculty of 1,000; selected for the Spotlight feature by the Editors of Journal of Virology
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