Which samples should be submitted when lymphoid neoplasia is suspected?
Which test should be submitted? The answer to this depends on the clinical signs, and the diagnostic question you are asking. In general, flow cytometry is preferred if it is possible to obtain a fresh sample. This is because flow cytometry can provide phenotypic information that PARR cannot. For example, if PARR demonstrates a clonally rearranged T cell receptor gene, that finding confirms neoplasia, but that neoplasm could be anything from an indolent T zone lymphoma to an acute lymphoblastic T cell lymphoma/leukemia. In rare cases, it could also be the result of a myeloid origin tumor.
One situation where PARR may be preferred is when only rare suspicious cells are noted in a sample. Even in these cases, it is usually best to try flow cytometry first, followed by PARR if the flow cytometry is inconclusive. PARR may be the only option to confirm neoplasia if a fresh sample cannot be obtained.
There are few antibodies for cats, and frequently both tests are needed to establish a diagnosis of neoplasia in feline patients.
Click on the link for each test to find out how to submit a sample. If cytology or histology give equivocal results, and/or you are seeking additional prognostic or diagnostic information, use the guidelines below to choose a test, or feel free to call the laboratory at (970) 491-1170 or email at email@example.com.