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Mosquito with west nile virus in the Arthopod-borne and Infectious Diseases Laboratory (AIDL)

 Welcome to the Arthropod-borne and Infectious Diseases Laboratory at Colorado State University.

Arthropod-borne and Infectious Diseases Laboratory

 
 

 Upcoming AIDL Events

 

​The Arthropod-borne and Infectious Disease Laboratory (AIDL) is a research center within the Department of Microbiology, Immunology and Pathology at CSU (Dr. Gregory Ebel: Director). Faculty at the AIDL facility and adjacent Infectious Disease Annex (IDA) engage in basic and applied research to promote a more complete understanding of pathogen transmission, persistence, and emergence with the goal of developing improved control of vector-borne and other zoonotic diseases. We are a broadly based, interactive, multi-disciplinary research and training unit that seeks to improve public health through the study of emerging zoonotic pathogens.

AIDL faculty members have ongoing collaborations with researchers at several national and international academic institutions, the Department of Defense, and the Centers for Disease Control and Prevention (Division of Vector-borne Infectious Diseases).

AIDL and the adjacent Regional Biocontainment Laboratory (RBL) possess state of the art animal containment facilities and insectaries for conducting investigations with zoonotic pathogens that cause human and animal diseases. We also have access to the nearby Research Innovation Complex (RIC) and CSU’s BioPharmaceutical Manufacturing and Academic Resource Center (BioMarc) to assist in moving research from laboratory-based discoveries to translational research initiatives and product development. Moreover, AIDL provides an outstanding scientific environment for researchers inside and outside CSU wanting to manipulate pathogens in vertebrate hosts and arthropod vectors.

The Primary Mission of AIDL is To:

  • Devise novel vector- and disease- control strategies by applying state-of-the-art approaches to the study of arthropod-borne virus interactions with vector and vertebrate hosts.
  • Develop rapid, clinically, and field relevant diagnostic assays for zoonotic diseases.
  • Determine the trafficking and emergence potential of vector-borne and rodent borne viruses in nature.
  • Determine the effects of genetic diversity of vectors, viruses, and host on vector-borne and rodent-borne virus persistence and emergence.
  • Provide training for students, post-docs, and scientists in conducting virus-vector interactions.

AIDL News and Recent Publications:

  • zika virus, aidl, brian geiss
    The AIDL's Brian Geiss recently published a paper stating that sofosbuvir, an FDA-approved nucleotide polymerase inhibitor for the distantly related hepatitis C virus, could have antiviral activity against ZIKV infection.
  • zika, brian foy, aidl, virus
    ​The first known sexual transmission of the Zika virus occurred years ago, and our own researcher knew about it.
  • PLOS, AIDL
    Within hosts, RNA viruses form populations that are genetically and phenotypically complex. Heterogeneity in RNA virus genomes arises due to error-prone replication and is reduced by stochastic and selective mechanisms that are incompletely understood. Defining how natural selection shapes RNA virus populations is critical because it can inform treatment paradigms and enhance control efforts.
  • PLOS, AIDL, Pub
    Globally, regions at the highest risk for emerging infectious diseases are often the ones with the fewest resources. As a result, implementing sustainable infectious disease surveillance systems in these regions is challenging. The cost of these programs and difficulties associated with collecting, storing and transporting relevant samples have hindered them in the regions where they are most needed.
  • zika, brian foy, aidl, virus
    The spread of Zika virus has become an international public health emergency as transmission explodes in Latin America and the Caribbean. Researchers in our Arthropod-borne and Infectious Diseases Laboratory offer seven key insights on the virus.​​​
  • asm
    To test the hypothesis that RNA interference (RNAi) imposes diversifying selection on RNA virus genomes, we quantified West Nile virus (WNV) quasispecies diversity after passage in Drosophila cells in which RNAi was left intact, depleted, or stimulated against WNV. As predicted, WNV diversity was significantly lower in RNAi-depleted cells and significantly greater in RNAi-stimulated cells relative to that in controls. These findings reveal that an innate immune defense can shape viral population structure.​​
  • rushika perera
    Have you heard the buzz? Rushika Perera was named a Boettcher Investigator and received funding to support her research in mosquito-borne viruses. She studies biochemical changes in the mosquito midgut that allow virus replication. ​​​
  • rushika perera
    ​Her colleagues know Rushika Perera for mosquito research aimed at halting viruses inside their buzzing vectors. She’s also a competitive ballroom dancer – proving that winning both in the lab and on the floor takes fancy footwork.​
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Contact Us:
1​692 Campus Delivery
Fort Collins, CO, 80523-1692

Phone:
(97​0) 491-8306

Fax:
​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​(970) ​491-8323​