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William H. Hanneman, Ph.D.

Professor,
Toxicology

Office: 115 Physiology
Office Phone: 970-491-5652
Email: william.hanneman@colostate.edu

Links:

Dr. Hanneman's PubMed Publications


Biography

Chemicals that cause nerve injury and neurological deficits are a structurally diverse group and not well understood. Cellular toxicity occurs when electrophilic adduct formation disrupts protein structure and/or function, which secondarily causes damage to organelles, metabolic pathways, and/or physiological processes. Since many neurotoxicants are also electrophiles, our laboratory has hypothesized that the corresponding pathophysiological mechanisms of neuroendocrine disruption involve protein adduction and dysfunction.


Degrees

Ph.D.: Toxicology, Texas A&M University, College Station, TX: 1995

M.S.: Physiology, California State Polytechnic University, Pomona, CA: 1990

B.S.: Animal Science, The University of California, Davis, CA: 1988


Selected Publications

The atrazine metabolite diaminochlorotriazine suppresses LH release from murine LßT2 cells by suppressing GnRH-induced intracellular calcium transients. Dooley GP, Tjalkens RB, Hanneman WH. Toxicol Res (Camb). 2013 May 1;2(3):180-186. PMID: 24052811 [PubMed]

Streifel KM, Moreno JA, Hanneman WH, Legare ME, Tjalkens RB. Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Toxicol Sci. 2012 Mar;126(1):183-92. PMID: 22174044.

Maeda J, Yurkon C, Fujisawa H, Kaneko M, Genet S, Hanneman WH, Thamm D and TA Kato. Genomic Instability and Telomere Fusion of Canine Osteosarcoma Cell Lines. PloS ONE. 2012;7(8). PMID: 22916246.

Dooley GP, Tjalkens RB, Ritz L and WH Hanneman. Chlorotriazine-induced alterations of cellular calcium signaling and LH release in L-Beta-T2 cells. Chemical Research and Toxicology Letters (Submitted)

Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Streifel KM, Moreno JA, Hanneman WH, Legare ME, Tjalkens RB. Toxicol Sci. 2011, PMID: 22174044

Cellular and phenotypic characterization of canine osteosarcoma cell lines. Legare ME, Bush J, Ashley AK, Kato T, Hanneman WH. J Cancer. 2011 May 4;2:262-70. PMID: 21552385

Manganese-induced NF-kappaB activation and nitrosative stress is decreased by estrogen in juvenile mice. Moreno JA, Streifel KM, Sullivan KA, Hanneman WH, Tjalkens RB. Toxicol Sci. 2011 Jul;122(1):121-33. PMID: 21512103

Proteomic analysis of diaminochlorotriazine (DACT) adducts in three brain regions of Wistar rats. Dooley GP, Ashley AK, Legare ME, Handa RJ, Hanneman WH. Toxicol Lett. 2010 Nov 10;199(1):17-21

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