Radiation Cancer Biology and Oncology
Office: 437 Molecular and Radiological Biosciences (MRB)
Office Phone: 970-491-2944
Dr. Bailey's PubMed Publications
Our Stories: Of Telomeres and Twins
NASA Twins Study News Release: Astronaut Alum Dr. Kjell Lindgren Visits CSU
The Twins Study Patch
Dr. Bailey is a Professor and Radiation Cancer Biologist in the Department of Environmental & Radiological Health Sciences (ERHS). Part of her current research program includes being one of 10 investigations selected by NASA for the TWINS Study, an integrated effort to launch human space life science research into a new era of molecular or "omics" based studies. As part of the one year mission aboard the International Space Station, identical twin astronauts Scott and Mark Kelly, are the subjects of this unique research opportunity. The overall goal of the TWINS Study is to identify space-flight specific factors that influence human health, important considerations as we spend longer and longer periods of time, deeper and deeper into space, making our way to Mars.
Bailey and her team are assessing changes in telomere length and telomerase activity in the space- and earth-bound twins, as well as in a cohort of unrelated astronauts, which includes CSU alum Dr. Kjell Lindgren. She proposes that telomere maintenance represents not only a key indicator of general health, but also a particularly relevant biomarker of aging and age-related degenerative diseases (e.g., cardiovascular disease and cancer), as it reflects the combined experiences (e.g., nutritional, psychological, and physical stresses) and environmental exposures (e.g., UV and ionizing radiations) encountered during spaceflight. Studies also include evaluating chromosome aberrations as specific biomarkers of radiation exposure. Taken together with the other TWINS Study investigations, results will facilitate identification of interactive effects and relationships that will suggest potential mitigation strategies for future study, as well as benefit precision medicine efforts in monitoring health and assessing disease risk not only of astronauts, but for those on earth as well.
Ph.D.: Biomedical Sciences, The University of New Mexico School of Medicine, Albuquerque, NM: 2000
M.S.: Biomedical Sciences, The University of New Mexico School of Medicine, Albuquerque, NM: 1996
B.S.: Biological Sciences, Colorado State University, Fort Collins, CO: 1976
Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis. Sishc BJ, Nelson CB, McKenna MJ, Battaglia CL, Herndon A, Idate R, Liber HL, Bailey SM. Frontiers in oncology. 2015; 5:257.
Stress and telomere shortening among central Indian conservation refugees. Zahran S, Snodgrass JG, Maranon DG, Upadhyay C, Granger DA, Bailey SM. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(9):E928-36.
Radiation quality and mutagenesis in human lymphoblastoid cells. Liber HL, Idate R, Warner C, Bailey SM. Radiation research. 2014; 182(4):390-5.
Le PN, Maranon DG, Altina NH, Battaglia CLR and Bailey SM (2013). TERRA, hnRNP A1, and DNA-PKcs interactions at human telomeres. Front. Oncol. 3:91. doi: 10.3389/fonc.2013.00091.
Ray FA, Zimmerman E, Robinson B, Cornforth MN, Bedford JS, Goodwin EH, Bailey SM (2013). Directional genomic hybridization for chromosomal inversion discovery and detection. Chromosome Res 21(2):165-74.
Quimby JM, Maranon DG, Battaglia CLR, McLeland SM, Brock WT, Bailey SM (2013). Feline chronic kidney desease is associated with shortened telomeres and increased cellular senescence. Am J Physiol Renal Physiol doi:10.1152/ajprenal.00527.
Douglas H. Thamm, Kristen K. Grunerud, Barbara J. Rose, David M. Vail, Susan M. Bailey (2013). DNA repair deficiency as a susceptibility marker for spontaneous lymphoma in golden retriever dogs: a case-control study. PLOS ONE 8(7)e69192.
Loucas BD, Durante M, Bailey SM, Cornforth MN. (2013). Chromosome Damage in Human Cells by ? Rays, a Particles and Heavy Ions: Track Interactions in Basic Dose-Response Relationships. Radiation Research 179(1):9-20.
Steffen LS, Bacher JW, Peng Y, Le PN, Ding L-H, Genik PC, Ray FA, Bedford JS, Fallgren CM, Bailey SM, Ullrich RL, Weil MM, Story MD. (2013). Molecular characterisation of murine acute myeloid leukaemia induced by 56Fe ion and 137Cs gamma ray irradiation. Mutagenesis 28(1):71–9.
Chernikova, S.B., Razorenova, O.V., Higgins, J.P., Sishc, B.J., Nicolau, M., Dorth, J.A., Chernikova, D.A., Kwok, S., Brooks, J.D., Bailey, S.M., Game, J.C. and Brown, J.M. (2012). Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1(Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability. Cancer Research 72:2111-2119.
Fabre KM, Ramaiah L. Dregalla RC, Desaintes C, Weil MM, Bailey SM, and Ullrich RL. Murine Prkdc polymorphisms impact DNA-PKcs function. Radiation Research 175, 493-500, 2011.
Eli S. Williams, Michael N. Cornforth, Edwin H. Goodwin, Susan M. Bailey, 2011. CO-FISH, COD-FISH, ReD-FISH, SKY-FISH. In: Telomeres and Telomerase: Methods and Protocols, Methods in Molecular Biology, Vol 735. Zhou Songyang (ed.), Humana Press.
Bedell HW, Battaglia CLR, Ray FA, Bailey SM. Confirmation of radiation-induced RET/PTC chromosome rearrangements in human thyroid cells. Journal for Undergraduate Research and Scholarly Excellence Colorado State University. Spring 2011 Vol II Issue 1
Telomere sister chromatid exchange and the process of aging. Blagoev KB, Goodwin EH, Bailey SM. Aging (Albany NY). 2010 Oct;2(10):727-30.
Chromosome Orientation fluorescence in situ hybridization or strand-specific FISH. Bailey SM, Williams ES, Cornforth MN, Goodwin EH. Methods Mol Biol. 2010;659:173-83.
Hyper telomere recombination accelerates replicative senescence and may promote premature aging. Hagelstrom RT, Blagoev KB, Niedernhofer LJ, Goodwin EH, Bailey SM. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15768-73. Epub 2010 Aug 23
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. Dregalla RC, Zhou J, Idate RR, Battaglia CL, Liber HL, Bailey SM. Aging (Albany NY). 2010 Oct;2(10):691-708.
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. Lam YC, Akhter S, Gu P, Ye J, Poulet A, Giraud-Panis MJ, Bailey SM, Gilson E, Legerski RJ, Chang S. EMBO J. 2010 Jul 7;29(13):2230-41. Epub 2010 Jun 15.