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Paula C. Genik, Ph.D.

Assistant Professor,
Radiation Cancer Biology and Oncology

Office: 493 Molecular and Radiological Biosciences (MRB)
Office Phone: 970-491-1087
Email: paula.genik@colostate.edu

Links:

Dr. Genik's NCBI Publications


Degrees

Ph.D.: Physiology and Cell Biology, Sherbrooke University, Sherbrooke, Canada: 1991

B.Sc.: Biology (Human Genetics and Neurobiology), McGill University, Montréal, Canada: 1979


Research Interests

Cancer Biology (Pancreas, Liver, GI, Breast, Leukemia/Lymphoma, Sarcoma)

Cancer Genetics and Genomics

Radiation Cancer Prevention, Radiation Carcinogenesis and Cancer Radiotherapy

Radiation quality, dose and dose rate (Cosmic and GCR, Diagnostic and Therapeutic Radiation)

Chronooncology: Chronocarcinogenesis, Chronoprevention and Chronotherapy

Chronobiology (Circadian)

Murine and Companion Animal Models

DNA Repair; Ploidy; Binucleated Cells

Diabetes


Selected Classes and Lectures

Chronooncology: Chronocarcinogenesis, Chronotherapy and Chronoprevention (Graduate Course – Fall 2018)

Chronocarcinogenesis: A 4D Circadian Perspective (lecture in CSU ERHS 733: Environmental Carcinogenesis)

Chemical Carcinogenesis (lecture in CSU ERHS 611: Cancer Genetics)

Tissue Culture (Graduate Course - Sherbrooke University)

Histology (Undergraduate Course - Sherbrooke University)

Genetics (Undergraduate Course - Sherbrooke University)


Selected Presentations/Talks

Genik PC. 2016. Radiation and Rhythms. Radiation Cancer Biology and Oncology Faculty Seminar Series - College of Veterinary Medicine and Biomedical Sciences - Department of Environmental and Radiological Health Sciences; 2016 May 20; Fort Collins, CO, USA.

Genik PC. 2013. Role of Circadian Rhythms and Genetic Background on Cosmic and Therapy-Related Leukemogenesis: A Pilot Study in Mouse Models. Gordon Research Conference: Chronobiology; July; Newport, Rhode Island, USA.

Bacher JW, Weil M, Vyazunova I, Steffen LS, Genik PC, Fallgren CM, Bailey SM, Le PN, Ray FA, Story MD, Ding LH, Yu Y, Ullrich RL. 2013. Molecular and Cytogenetic Characterization of High LET and Low LET Radiation Induced AML in Mouse. Joint Meeting, 24th NASA Space Radiation Investigators’ Meeting, 6th International Workshop for Space Radiation Research, 14th International Workshop on Ion Beam in Biology and Medicine, 5th ESA Space Radiation Investigators Meeting and 1st Japanese Association of Space Radiation Research Meeting. HITSRS 2013, Chiba, Japan.; 2013; Chiba, Japan.

Genik PC. 2012. The rAML-PU.1 Paradigm: Time for a Shift? Invited Talk. National Institute of Radiological Sciences; January; Chiba, Japan.

Eidus* LB, Genik* PC, Robertson S, Maroun JA, Birnboim HC. 1994. A New Fixative for Molecular Biology and Diagnostic Pathology. FASEB Annual Meeting; 1994 April; Annaheim, California, USA. FASEB Journal. 8 (11): 888pp.

Genik PC, Morisset JA. 1987. Circadian Profile of the Adult Rat Pancreas: Biochemical and Biosynthetic Considerations. Gastroenterology 94 (5, 2): pp 169. American Gastroenterology Association; 1989 May 17; Chicago, IL, USA.  

Genik PC, Morisset JA. 1987. Caerulein Alters the Nucleation Profile of the Pancreatic Acinar Parenchyma. Gastroenterology 92 (5, 2): pp 1402. American Gastroenterology Association Annual Meeting; May.


Selected Publications

Hanglun Yu, Alison H. Doherty, Paula C Genik, Sara E. Gookin, Danielle Roteliuk, Samantha J Wojda, Zhi-Sheng Jiang, Meghan E McGee-Lawrence, Michael M Weil, Seth W Donahue. 2017. “Mimicking the effects of disuse and chronic low-dose rate radiation exposure on bone mass in mice”. Life Sciences in Space Research (November) 15: 62-68.

Weil MM, Ray FA, Genik PC, Yu Y, McCarthy M, Fallgren CM, Ullrich RL. 2014.
Effects of 28Si ions, 56Fe ions, and protons on the induction of murine acute myeloid leukemia and hepatocellular carcinoma. PloS one. 9(7):e104819.

Genik PC, Bielefeldt-Ohmann H, Liu X, Story MD, Ding L, Bush JM, Fallgren CM, Weil MM. 2014. Strain background determines lymphoma incidence in Atm knockout mice. Neoplasia (New York, N.Y.). 16(2):129-36.
 
Ochola D, Fallgren C, Hauss C, Joyce J, Genik P, Bedford J, Weil M. 2014. Modification of Histone Gamma H2AX Can Be Used as a Marker to Predict Susceptibility to Lung Tumor Development. Keystone Symposium on Cancer Epigenetics; February; Santa Fe, NM, USA.
 
Genik PC, Vyazunova I, Steffen LS, Bacher JW, Bielefeldt-Ohmann H, McKercher S, Ullrich RL, Fallgren CM, Weil MM, Ray FA. 2014. Leukemogenesis in heterozygous PU.1 knockout mice.
Radiation Research. 182(3):310-5.
 
Maeda J, Bell JJ, Genet SC, Fujii Y, Genet MD, Brents CA, Genik PC, Kato TA. 2014. Potentially lethal damage repair in drug arrested G2-phase cells after radiation exposure.
Radiation Research. 2014; 182(4):448-57.
 
Steffen LS, Bacher JW, Peng Y, Le PN, Ding LH, Genik PC, Ray FA, Bedford JS, Fallgren CM, Bailey SM, Ullrich RL, Weil MM, Story MD. 2013. Molecular characterization of murine acute myeloid leukaemia induced by 56Fe ion and 137Cs gamma ray irradiation. Mutagenesis. 28(1):71-9.
 
Fujisawa H, Genik PC, Kitamura H, Fujimori A, Uesaka M, Kato TA. 2013. Comparison of human chordoma cell-kill for 290 MeV/n carbon ions versus 70 MeV protons in vitro. Radiation Oncology (London, England). 8:91.
 
Bielefeldt-Ohmann* H, Genik* PC, Fallgren CM, Ullrich RL, Weil MM. 2012. Animal studies of charged particle-induced carcinogenesis. Health physics. 103 (5):568-76.
 
Genet SC, Maeda J, Fujisawa H, Yurkon CR, Fujii Y, Romero AM, Genik PC, Fujimori A, Kitamura H, Kato TA. 2012. Comparison of cellular lethality in DNA repair-proficient or -deficient cell lines resulting from exposure to 70 MeV/n protons or 290 MeV/n carbon ions.
Oncology Reports. 28(5):1591-6.
 
Peng Y, Brown N, Finnon R, Warner CL, Liu X, Genik PC, Callan MA, Ray FA, Borak TB, Badie C, Bouffler SD, Ullrich RL, Bedford JS, Weil MM. 2009. Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma rays. Part I. Experimental observations. Radiation Research. 171(4):474-83.
 
Weil MM, Bedford JS, Bielefeldt-Ohmann H, Ray FA, Genik PC, Ehrhart EJ, Fallgren CM, Hailu F, Battaglia CL, Charles B, Callan MA, Ullrich RL. 2009. Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ions. Radiation Research. 172(2):213-9.
 
Ahuja AK, Barber RC, Hardwick RJ, Weil MM, Genik PC, Brenner DJ, Dubrova YE. 2008. The effects of Atm haploinsufficiency on mutation rate in the mouse germ line and somatic tissue.
Mutagenesis. 23(5):367-70.
 
Kato TA, Nagasawa H, Weil MM, Genik PC, Little JB, Bedford JS. 2006. gamma-H2AX foci after low-dose-rate irradiation reveal atm haploinsufficiency in mice.
Radiation Research. 166(1 Pt 1):47-54.
 
Genik, PC. 1991. On the Interdependence of Pancreatic Size, Tissue Composition, Cellularity and Growth. THESIS ed. Ottawa, Canada: National Library of Canada; Chapter III, Circadian-Stage-Dependent Profile of Pancreatic Tissue Composition in the Adult Rat; p.20-105.
 
Genik, PC. 1991. On the Interdependence of Pancreatic Size, Tissue Composition, Cellularity and Growth. THESIS ed. Ottawa, Canada: National Library of Canada; 1991. Chapter Appendix VIII, Literature Survey of Circadian-Stage-Variability of the Pancreas; p.470-478.
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