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Marie E. Legare, D.V.M., Ph.D.

Associate Professor,
Toxicology

Office: 133 Physiology
Office Phone: 970-491-7043
Email: marie.legare@colostate.edu

Links:

Dr. Legare's PubMed Publications


Biography

Dr. Legare’s research interest is in the analysis of genes and gene expression. She is interested in how lead, mercury, pesticide residues and other agents influence health and risk of disease. Her laboratory has several different ongoing projects, including a March of Dimes grant to identify genes that are disregulated after exposure to alcohol. A second study is examining the exposure of embryonic stem cells to environmental chemicals and how genes are impacted.Dr. Legare’s research interest is in the analysis of genes and gene expression. She is interested in how lead, mercury, pesticide residues and other agents influence health and risk of disease. Her laboratory has several different projects on-going, including a March of Dimes grant to identify genes that are disregulated after exposure to alcohol. A second study is examining the exposure of embryonic stem cells to environmental chemicals and how genes are impacted.


Degrees

Ph.D.: Veterinary Anatomy, Texas A&M University, College Station, TX: 1995

D.V.M.: Texas A&M University, College Station, TX: 1991

M.S.: Biomedical Science, Montana State University, Bozeman, MT: 1983

B.S.: Zoology, Montana State University, Bozeman, MT: 1979.


Selected Publications

Significance of ERa, HER2, and CAV1 expression and molecular subtype classification to canine mammary gland tumor. J Vet Diagn Invest 2014 Apr 23;26(3):390-403

Determination of Illicit Drug on the Hands of High Volume Money Collectors using LC-MS/MS. SOT The Toxicologist 2014.

Gene Deletion of NOS2 protects against manganese-induced neurological dysfunction in juvenile mice. Streifel KM, Moreno JA, Hanneman WH, Legare ME, Tjalkens RB. Toxicol Sci 2012 126(1):183-92

Prenatal Dexamethasone Exposure Potentiates Diet-Induced Hepatosteatosis and Decreases Plasma IGF-1 in a Sex-specific Fashion. Carbone DL, Zuloaga DG, Hiroi R, Foradori CD, Legare ME, Handa RJ. Endocrinology 2012 153(1):295-306.

Legare ME, Bush J, Ashley AK, Kato T, Hanneman WH. Cellular and phenotypic characterization of canine osteosarcoma cell lines. J Cancer May 2011 2:262-70

Streifel, KM, Moreno JA, Hanneman WH, Legare ME, Tjalkens RB. Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Toxicol Sci 2011

Carbone DL, Zuloaga DG, Hiroi R, Foradori CD, Legare ME, Handa RJ. Prenatal dexamethasone exposure potentiates diet-induced hepatosteatosis and decreases plasma IgF-1 in a sex-specific fashion. Endocrinology Nov 2011.

Dooley GP, Ashley AK, Legare ME, Handa R, Hanneman WH. 2010. Proteomic Analysis of Diaminochlorotriazine Adducts in Three Brain Regions and GT1-7 Cells. Toxicol Lett 17-21

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