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J. Lucas Argueso, Ph.D.

Associate Professor and Boettcher Investigator,
Radation Cancer Biology and Oncology

Office: 493 Molecular and Radiological Biosciences (MRB)
Office Phone: 970-491-3681


Dr. Argueso's PubMed Publications

Dr. Argueso's ORCID





Ph.D.: Genetics and Development, Cornell University, Ithaca, NY: 2004

M.S.: Genetics and Plant Breeding, The University of São Paulo, São Paulo, Brazil: 1997

B.S.: Argonomic Engineering, The University of São Paulo, São Paulo, Brazil: 1995

Research Interests

Dr. Argueso's research interests include:

  • Chromosomal rearrangements and phenotypic consequences of altered genome architecture.

  • Effects of environmental exposure on copy number variation (CNV) and chromosome structure

  • Molecular mechanisms of DNA double-strand break repair.

  • Structural genome variation in natural yeast populations.

  • Genomics of industrial yeast strains and bioethanol fermentation.

Selected Publications

Carvalho-Netto OV, Carazzolle MF, Mofatto LS, Teixeira P, Noronha MF, Calderón L, Mieczkowski PA, Argueso J. L., Pereira G. 2015 Saccharomyces cerevisiae transcriptional reprograming due to bacterial contamination during industrial scale bioethanol production. Microbial Cell Factories 14: 13.

Yadav, P., Harcy, V., Argueso, J. L., Dominska, M., Jinks-Robertson, S. Kim, N.  2014  Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence. PLoS Genetics, 10: e1004839. 

Vasan, S., Deem, A., Ramakrishnan, S., Argueso, J. L., Malkova, A.  2014  Cascades of genetic instability resulting from compromised break-induced replication. PLoS Genetics, 10: e1004119.

Covo, S., Puccia, C. M., Argueso, J. L., Gordenin, D. A., Resnick, M. A.  2014  The sister chromatid cohesion pathway suppresses multiple chromosome gain and chromosome amplification. Genetics, 196: 373-384.
*This article was featured in Genetics’ February 2014 issue “Highlights Section”.

Zhang, H., Zeidler, A. F. B., Song, W., Puccia, C. M., Malc, E., Greenwell, P. W., Mieczkowski, P. A., Petes, T. D., Argueso, J. L.  2013  Gene copy number variation (CNV) in haploid and diploid strains of the yeast Saccharomyces cerevisiae. Genetics 193: 785-801.

Yauk, C. L., Argueso, J. L., Auerbach, S. S., Awadalla, P., Davis, S. R., Demarini, D. M., et al.  2013  Harnessing genomics to identify environmental determinants of heritable disease. Mutation Research 752: 6-9.

Nishant, K. T., Wei, W., Mancera, E., Argueso, J. L., Schlattl, A., Delhomme, N., Ma, X., Bustamante, C., Korbel, J. O., Gu, Z., Steinmetz, L. M., Alani, E.  2010  The baker’s yeast diploid genome is remarkably stable in vegetative growth and meiosis. PLoS Genetics, 6: e1001109.
Argueso, J. L., Carazzolle, M. F., Mieczkowski, P. A., Duarte, F. M., Netto, O. V. C., Missawa, S. K., Galzerani, F., Costa, G. G. L., Vidal, R. O., Noronha, M. F., Dominska, M., Andrietta, M. G. S., Andrietta, S. R., Cunha, A. F., Gomes, L. H., Tavares, F. C. A., Alcarde, A. R., Dietrich, F. S., McCusker, J. H., Petes, T. D., Pereira, G. A. G. 2009  Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production. Genome Research, 19: 2258-2270.
*This article was featured in Genome Research's issue cover.
*This article was featured in the Current Topics section of Microbe Magazine (Microbe, 5:45).
*This article was included in the list of "Seminal Yeast Literature" compiled by the curators of Saccharomyces Genome Database comprising "landmark papers in yeast biology".

Argueso, J. L., Westmoreland, J., Mieczkowski, P. A., Gawel, M., Petes, T. D., Resnick, M. A.  2008 Double strand breaks associated with repetitive DNA can reshape the genome.  Proceedings of National Academy of Sciences of the United States of America, 105: 11845-11850.
*This article was featured in PNAS' issue cover and Commentaries section (PNAS, 105: 11593).
 *This article was featured in Science Magazine Editors' Choice section (Science, 321: 892).
 *This article was recommended in F1000Prime as exceptional; highest rating.

Surtees, J. A., Argueso, J. L., Alani, E.  2004  Mismatch repair proteins: Key regulators of genetic recombination.  Cytogenetic and Genome Research 107: 146-159.

Argueso, J. L., Wanat, J., Gemici, Z., Alani, E.  2004 Competing crossover pathways act during meiosis in Saccharomyces cerevisiae. Genetics 168: 1805-1816.
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