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Jac A. Nickoloff, Ph.D.

Professor and Department Head

Office: 433 Molecular and Radiological Biosciences (MRB)
Office Phone: 970-491-6674
Email: j.nickoloff@colostate.edu

Links:

Dr. Nickoloff's PubMed Publications

 

MacArthur References

 

 

 


Biography

Dr. Nickoloff is a Professor of Cancer Biology and Head of the Dept. of Environmental and Radiological Health Sciences. The Nickoloff laboratory studies the molecular mechanisms that maintain eukaryotic genome stability in response to stress induced by DNA damage caused by low and high LET ionizing radiation and by genotoxic chemicals including cancer chemotherapeutics. Studies focus on DNA damage response networks including signaling pathways, checkpoint responses, chromatin regulatory systems and DNA repair pathways including homologous recombination and nonhomologous end-joining. Both yeast and mammalian cell systems are employed in studies involving the induction, mechanisms, consequences and genetic control of DNA damage responses. Dr. Nickoloff collaborates with scientists in Japan, England, Germany, the University of Colorado, the University of Nebraska and the University of Florida to improve our understanding of normal and tumor cell responses to radiotherapy and chemotherapy.


Degrees

Ph.D.: Biochemistry, The University of Colorado, Boulder, CO: 1983

B.A.: Biochemistry, The University of California, Santa Barbara, CA: 1978


International Collaboration


Japan; National Institute of Radiological Sciences; genetic retulation of cell responses to heavy ion radiation

England; University of Sussex; repair of DNA damage caused by heavy ion radiation

Germany; GSI Helmholtz Centre for Heavy Ion Research; tumor hypoxia and regulation of Phoenix Rising tumor repopulation pathway


Selected Publications


Allen, C., Ashley, A.K., Hromas, R., and Nickoloff, J.A. (2011) More forks on the road to replication stress recovery. J. Mol. Cell Biol. 3, 4-12.
 
Allen, C.P., Borak, T.B., Tsujii, H., and Nickoloff, J.A. (2011) Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy. Mutat. Res. 711, 150–157.
 
Hromas, R., Williamson, E., Fnu, S., Lee, Y.-J., Park, S.-J., Beck, B.D., You, J.-S., Laitao, A., Nickoloff, J.A., and Lee, S.-H. (2012) Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart. Oncogene 31, 4245-4254.
 
Musselman, C.A., Avvakumov, N., Watanabe, R., Abraham, C.G., Lalonde, M.E., Hong, Z., Allen, C., Roy, S., Nuñez, J.K., Nickoloff, J., Kulesza, C.A., Yasui, A., Côté, J., Kutateladze T.G. (2012) Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat. Struct. Mol. Biol. 19, 1266-1272.
 
Liu, S., Opiyo, S.O., Manthey, K., Glanzer, J.G., Ashley, A.K., Troksa, K., Shrivastav, M., Nickoloff, J.A., and Oakley, G.G. (2012) Distinct roles for DNA-PK, ATM, and ATR in RPA phosphorylation and checkpoint activation in response to replication stress. Nucleic Acids Res. 40,10780-10794.
 
Williamson, E.A., Damiani, L., Leitao, A., Hu, C., Hathaway, H., Oprea, T., Sklar, L., Shaheen, M., Bauman, J., Wang, W., Nickoloff, J.A., Lee, S.-H., and Hromas, R. (2012). Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy. Cancer Res. 72, 6200-6208.
 
Nickoloff, J.A. (2013) Improving cancer therapy by combining cell biological, physical, and molecular targeting strategies. Chinese J. Cancer Res. 25, 7-9.
 
Wray, J., Williamson, E.A., Singh, S.B., Wu, Y., Cogle, C.R., Weinstock, D.A., Zhang, Y., Lee, S.-H., Zhou, D., Shou, L., Hauer-Jensen, M., Pathak, R., Klimek, V., Nickoloff, J.A., and Hromas, R. (2013) PARP1 is required for chromosomal translocations. Blood 121, 4359-4365.
 
Nickoloff, J.A. (2013). Assaying DNA double-strand break induction and repair as fast as a speeding comet. Cell Cycle 12, 1161–1165.
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