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Orthopaedic Research Center Collaborators from Other Institutes

Alan Boyde, B.D.S., L.D.S., Ph.D.

Professor, Department of Anatomy and Developmental Biology, University College London
Dr. Boyde is the author of many papers, chapters, and abstracts on the development, structure, and mineralization of bone, age changes in skeletal tissue, and osteoporosis. He has developed enabling technologies for the microscopic investigation of mineralized tissues and cell biology.
Honors include: Wellcome Trust Biomedical Imaging Awards for Excellence, 1998 and 2002; President of the Anatomical Society of Great Britain and Ireland, 2002-2004; Elected Honorary Member of Bone and Tooth Society, 2002.

Neil David Broom, Ph.D.

Associate Professor, Department of Chemical and Materials Engineering, University of Auckland
Dr. Broom's doctoral studies were concerned with mechanical and ultrastructural analysis of the high velocity deformation of metal single crystals. He was personally responsible for establishing the first transmission electron microscopy facility in New Zealand permitting quantitative crystallographic analysis of crystal dislocation structures. His postdoctoral research at University of Cambridge was concerned with fundamental structural (TEM) and mechanical studies of intermetallic single crystal fibers relevant to the development of high strength lightweight metal fiber-reinforced metal composites of interest to the UK aircraft industry. Since 1975, Dr. Broom has been funded continuously by the New Zealand Medical Research Council and Health Research Council to conduct biomechanical/biomaterials research in heart valve biomechanics, joint tissue biomechanics/biomaterials, and intervertebral disc biomechanics.
Honors Include: University of Auckland Distinguished Teaching Medal, 1998; Engineering Faculty Award for Excellence in Undergraduate Teaching, 1999-2002.

Stephanie Bryant, Ph.D.

Assistant Professor, Department of Chemical and Biological Engineering, University of Colorado

Bruce Caterson, Ph.D.

Professor Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Associate Director of Musculoskeletal Research, School of Medicine, Cardiff University, U.K.
Dr. Caterson is a Professor in the Cardiff School of Biosciences and is currently Associate Director of Musculoskeletal Research in the School of Medicine. He was previously head of Connective Tissue Biology at Cardiff and prior to that was the Norfleet-Raney Professor of Research in Orthopaedics and Professor of Biochemistry and Biophysics at the University of North Carolina, Chapel Hill School of Medicine. He is world renowned in articular cartilage biochemistry and pioneered the use of monoclonal and polyclonal antibodies as biomarkers of joint disease. He has received the Kappa Delta Elizabeth Winston Lanier Award for Outstanding Orthopaedic Research from the American Academy of Orthopaedic Surgeons and Orthopaedic Research Society in 1998 and currently has large programme grant from the Arthritis Research Campaign on mechanisms of matrix proteoglycan catabolism in articular cartilage as well as EPSRC Platform Grant on bioresponsive polymer therapeutics: synthesis and characterization of novel nanomedicines.

Chris Evans, Ph.D.

Professor, Brigham and Women's Hospital, Center for Molecular Orthopaedics, Harvard University, Boston, Mass.
Dr. Evans is world-renowned in the area of human joint disease research, particularly in the use of gene therapy to treat arthritis. He was an outside member on the Ph.D. Committee of Dr. Dave Frisbie when he worked on his gene therapy with interleukin-1 receptor antagonist to treat equine traumatic arthritis and osteoarthritis. He continues to collaborate with the scientists at the Orthopaedic Research Center at CSU.
Honors include: Kappa Delta Award, AAOS; the Cabaud Award, American Society for Sports Medicine; the Henry Kunkle Award, American College of Rheumatology; Osteoarthritis Research Award, OARSI; and the Synos Award for Orthopaedic Research (with Paul Robbins), Synos Foundation.

Steven C. Ghivizzani, Ph.D.

Associate Professor, Research Division; Departments of Orthopaedics and Rehabilitation and Molecular Genetics & Microbiology, Gene Therapy Laboratory, University of Florida, Gainesville, Fla.
Dr. Ghivizzani is an Associate Professor in the Gene Therapy Laboratory at the University of Florida. He has collaborated with the Orthopaedic Research Center on several projects. Currently, he is working with the CSU researchers on adeno-associate virus and lenti virus delivery of interleukin-1 receptor antagonist.

Alan J. Grodzinsky, Sc.D.

Professor, Director of the MIT Center for Biomedical Engineering, Department of Mechanical Engineering and Biological Engineering Division, MIT
Dr. Grodzinsky is a Professor in the departments of Electrical, Mechanical, and Biological Engineering at the Massachusetts Institute of Technology. He is also the Director of the MIT Center for Biomedical Engineering. Dr. Grodzinsky research focuses on the mechanobiology of articular cartilage, including the response of native tissue to physiological and injurious loading as well as the mechanobiology of neo-tissue development for applications to cartilage resurfacing.

Charles Ho, M.D., Ph.D.

Director Imaging Research, Scientific Advisory Board Steadman Philippon Research Institute
Dr. Ho is experienced and active in musculoskeletal and sports medicine imaging and research, particularly in musculoskeletal Magnetic Resonance Imaging. He is a member of the Radiological Society of North America, the American Roentgen Ray Society, the American Academy of Orthopaedic Surgeons, the American Orthopaedic Society for Sports Medicine, and the ACL Study Group, among other professional organizations. He has published numerous papers and book chapters in the radiologic and orthopedic literature, and presented numerous papers internationally in radiologic and orthopedic conference proceedings. Dr. Ho is Director of Imaging Research and a member of the Scientific Advisory Board of the Steadman Philippon Research Institute in Vail, Colo. He has served as Radiologic Consultant for the San Francisco 49ers, the San Francisco Giants, Cleveland Indians, Denver Broncos, Colorado Rockies, the U.S. Ski Team, and the U.S. Decathlon Team.

Chris Little, B.Sc., B.V.M.S., M.Sc., Ph.D., Diplomate ACVS

Associate Professor and Director, Raymond Purves Bone & Joint Research Laboratories, University of Sydney Department of Orthopaedics & Traumatic Surgery, Royal North Shore Hospital
Dr. Little received his veterinary training at Murdoch University in Western Australia, where he also undertook an internship in equine medicine and surgery (1978-1984). He then completed a residency in large animal surgery and an M.Sc. studying arthritis in horses at the University of Minnesota. Chris was appointed to the faculty at the Ontario Veterinary College, University of Guelph and during this time passed his certifying examinations to become a Diplomate of the American College of Veterinary Surgeons (1990). He then moved to back to Australia and was awarded a Ph.D. degree from the Faculty of Medicine at the University of Sydney in 1996. Following a 5 year postdoctoral position at Cardiff University School of Biosciences in the UK, he was granted a two year Arthritis Foundation of Australia Ulysses Research Fellowship at the University of Melbourne. In 2004 he was appointed as Director of the Raymond Purves Bone & Joint Research Laboratories at the Royal North Shore Hospital, University of Sydney. Chris's research interests centre on the biochemical and molecular mechanisms of cartilage and more recently tendon breakdown in disease. In particular he has studied changes in aggrecan and small proteoglycan biosynthesis and degradation and the proteolytic pathways responsible in cartilage breakdown in arthritis and during tendon degeneration. Chris has been extensively involved in the development and use of neoepitope antibody methodologies, novel animal models, and most recently genetically modified mice, to study disease pathways. He has received over $3 million in basic and industrial research grants and has authored/ co-authored 53 papers and six book chapters.

Marcus G. Pandy, Ph.D.

Professor, Chair of Mechanical and Biomedical Engineering, Department of Mechanical and Manufacturing Engineering, University of Melbourne, Melbourne, Australia
Dr. Pandy is a Professor at the University of Melbourne and a leader in the study of musculoskeletal biomechanics. He is interested in applying the principles of mechanics and control theory to describe and explain the relationships between structure and function of the human body. By combining data obtained from biomechanical experiments with detailed computer models of the neuromusculoskeletal system, he is able to determine muscle, ligament, and joint loading during movement. Dr. Pandy is currently collaborating with CSU Orthopaedic researchers to develop a computer model of the entire equine forelimb to aid in the early detection of joint disease in horses.

Michael "Mick" Peterson, Ph.D.

Associate Professor, University of Maine
Dr. Peterson is Libra Foundation Professor of Mechanical Engineering at the University of Maine. Prior to coming to the University of Maine, he was a faculty member at Colorado State University and was a Post-Doctoral Researcher at Northwestern University. He has also worked in industry at General Motors and General Dynamics Corp. His Ph.D. is in Theoretical and Applied Mechanics from Northwestern University in Illinois, and he also holds a B.S. in Mechanical Engineering from General Motors Institute (now Kettering University) and an M.S. in Theoretical and Applied Mechanics from Northwestern University. He has also done additional graduate work in Mechanics, Materials, and Mathematics from Yale University, Cornell University, and the University of Connecticut. His primary expertise is in the dynamic responsive materials and waves in solids.

A. Robin Poole, Ph.D.

Professor Emeritus, Director of Joint Diseases Laboratory, McGill University, Montreal, Quebec
Dr. Poole is a pioneer in the use of markers in the early diagnosis of arthritis before other imaging techniques can reveal change. He is a world-renowned arthritis researcher, having previously led arguably the most prominent laboratory in the world in this area of research. He was the mentor of Dr. Billinghurst, and Dr. McIlwraith spent time with him on sabbatical leave. He is the co-author of two publications from the CSU Orthopaedic Laboratory. He is now retired but continues to be active and most recently was a keynote speaker at our 2009 Havemeyer Symposium on Biomarkers.
Honors include: Kappa Delta Award of the American Academy of Orthopaedic Surgeons, the Howard and Martha Holley Research Prize in Rheumatology, Carol Nachman International Prize for Rheumatology.

Christopher B. Riley, B.Sc.(Physics), B.V.Sc. (Hons), M.Sc., Ph.D., Diplomate ACVS

Associate Professor and Service Chief of Large Animal Surgery Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown PE Canada
Following military service in the Royal Australian Air Force, Dr. Riley received degrees in physics and veterinary medicine from the University of Melbourne, Australia. After time spent in an internship and private practice in Australia, he completed a surgical residency at the University of Saskatchewan in Canada. Concurrently he completed M.Sc. and Ph.D. degrees in the fields of tendon in-vitro biology and biochemistry. Dr. Riley then worked at briefly at Iowa State University and in private practice during which time he became Board certified as a Diplomate in the American College of Veterinary Surgeons. He joined the faculty at the Atlantic Veterinary College, Canada in 1999 where he is currently an Associate Professor and Service Chief of Large Animal Surgery. Following the granting of tenure, Dr. Riley has focused his research on the development of biomedical tests for animal diseases using the emerging technologies of infrared spectroscopy and bioinformatics. He established the first laboratory of its kind in Canada, developed to investigate the veterinary potential biomedical infrared spectroscopy. Dr. Riley has a special interest in orthopedic disease, but is also interested exploring the full potential of infrared technology as it applies to veterinary and comparative medicine. Dr. Riley has partnered with the workers from the Orthopaedic Research Center at Colorado State University, and the Institute for Biodiagnostics, National Research Council of Canada, to develop the first infrared test for equine traumatic arthritis in the world. He looks further to continued collaboration and advances in this new field of research.

Paul D. Robbins, Ph.D.

Professor of Molecular Genetics and Biochemistry and Orthopaedic Surgery, University of Pittsburgh School of Medicine, Director of the Vector Core Facility and Basic Research for the Molecular Medicine Institute
Dr. Robbins is currently a Professor of Molecular Genetics and Biochemistry and Orthopaedic Surgery at the University of Pittsburgh School Of Medicine. He is also Director of the Vector Core Facility and Director of Basic Research for the Molecular Medicine Institute. He received his Ph.D. from the University of California at Berkeley and worked as a post-doctoral fellow at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology. He is an Associate Editor for Cancer Research and Gene Therapy as well as on the Editorial Boards for Cancer Gene Therapy, The Journal of Gene Medicine, Arthritis Research, and Genes & Immunity. Dr. Robbins has co-authored over 180 peer-reviewed manuscripts, 110 book chapters and reviews, and has edited two books on gene therapy. He is a member of the PathB study section, the Telethon Scientific Review Committee and the Scientific Review Board of National Gene Vector Laboratory.

Robert Lie-Yuan Sah, M.D., Sc.D.

Professor and Vice-Chair of Bioengineering Affiliate in Orthopaedics, UCSD
Dr. Sah received his Sc.D. in Biomedical Engineering from the Massachusetts Institute of Technology and his M.D. from Harvard Medical School. He did postdoctoral work at Massachusetts General Hospital in Orthopaedic Bioengineering. He is currently a reviewer for Arthritis Foundation, NIH, NSF and Orthopaedic Research & Education Foundation, and the 2004 Chair of Gordon Research Conference on Musculoskeletal Biology and Bioengineering.
Honors include: "Mechanical Blueprint for Cartilage" cited as one of the Great Advances in Scientific Discovery in Disease and Injury Treatment, The Science Coalition, 1998; Accelerated academic advancements, UCSD, 1999 and 2001; American Academy of Orthopaedic Surgeons Kappa Delta Young Investigator Award, 2001; American Academy of Orthopaedic Surgeons Best Poster Award, 2003.

Roger K.W. Smith, M.A. VetMB Ph.D. DEO DipECVS MRCVS

Professor of Equine Orthopaedics, Royal Veterinary College, London, United Kingdom
Roger Smith qualified as a veterinary surgeon from Cambridge University in 1987 and, after two years in practice, returned to academia to undertake further clinical training as a Resident in Equine Studies at the Royal Veterinary College. Following his residency, he undertook a three-year research project culminating in the award of a Ph.D. for his studies on the extracellular matrix of equine tendon. He remained at the Royal Veterinary College, first as a Lecturer in Equine Surgery, then as Senior Lecturer in Equine Surgery before his appointment to a Professorship in December 2003. He holds the Diploma of Equine Orthopaedics from the Royal College of Veterinary Surgeons, and is both a Diplomate of the European College of Veterinary Surgeons and a Royal College of Veterinary Surgeons Specialist in Equine Surgery. He currently divides his time equally between running a specialist orthopaedic service within the Royal Veterinary College and continuing to direct research into equine tendon disease. His main area of research is understanding the mechanisms of tendon ageing but also has projects investigating the epidemiology of tendon disease in the horse, the development of a serological assay for tendonitis, and stem cell therapy for tendons in conjunction with a commercial company, VetCell Bioscience Ltd.

J. Richard Steadman, M.D.

Head of the Steadman Clinic and Steadman Philippon Research Institute, Vail, Colo.
Dr. Steadman graduated from the University of Texas Southwestern Medical School in Dallas. Following internship, two years in the army, and an orthopaedics residency at Charity Hospital in New Orleans, La., Dr. Steadman moved to Lake Tahoe, Calif., where he practiced orthopaedics with increasing emphasis on the treatment of knee disorders. While living there, he was named Chief Physician for the United States Ski Team. During his time at Lake Tahoe, Dr. Steadman developed special surgical techniques which allowed several ski team members to return to competition and win Olympic medals and championships. At Lake Tahoe, Dr. Steadman started a non-profit sports medicine foundation in order to conduct research in knee surgery and rehabilitation projects. That organization exists today as the Steadman Hawkins Sports Medicine Foundation in Vail, Colo. In 1990, Dr. Steadman moved to Vail, Colo., and was joined in practice there by Dr. Richard Hawkins, a specialist in shoulder disorders. By this time, Dr. Steadman had limited his practice to the surgical and conservative treatment of knee disorders. Today, Dr. Steadman is regarded as a world-renowned human orthopaedic surgeon. He is a prominent knee surgeon and the inventor of two significant new techniques in orthopaedics. His Foundation has supported several research projects at CSU. Dr. Steadman serves as a consultant regarding clinical relevance of our research work, and the CSU orthopaedic research lab has done controlled studies investigating his techniques used in human orthopaedic surgery.

Brigitte von Rechenberg, Dr. med. vet., Diplomate ECVS

University of Zurich
Honors include: SSRS Award 1996-1997 for the abstract, "Spontaneous production of nitric oxide and prostaglandin E2 in media of cartilage explants."

René van Weeren, D.V.M., Ph.D.

Diplomate European College of Veterinary Surgeons and Specialist in Equine Surgery, Royal Dutch Veterinary Association; Associate Professor, Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
Paul René van Weeren (1957) graduated in 1983 "cum laude" from the Utrecht University Veterinary Faculty (The Netherlands). He obtained his Ph.D. degree in 1989 and became a Diplomate of the European College of Veterinary Surgeons in 1994. Currently he is the coordinator of scientific research of the Department of Equine Sciences of the Faculty of Veterinary Medicine of Utrecht University and a member of the Management Board of the Department. His special interest is in equine orthopaedics. He has been a supervisor of 14 Ph.D. students, who have obtained their degree in the past years and currently supervises five Ph.D. students, who will be graduating within the next few years. He is a member of the board of reviewers of the American Journal of Veterinary Research and a member of the advisory board of Equine Veterinary Journal. He has been external examiner for Ph.D. students abroad at various occasions in the UK, France, Austria, Sweden, and Finland. He is author or co-author of more than 150 peer-reviewed scientific publications or book chapters.
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