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Faculty and Research Interests

Dr. Avery is an Associate Professor in the Department of Microbiology, Immunology, and Pathology at Colorado State University.  Her lab is investigating prognostic features for canine lymphoma.  Dr. Avery oversees a clinical diagnostic lab that provides flow cytometry and lymphoma molecular diagnostic service for veterinarians across the U.S.

​Dr. Bradley is a post-DVM fellow in the Department of Clinical Sciences.  She is investigating the pathogenesis of chronic liver disease in Standard Poodle dogs, as well as the use of novel immune suppressants for treatment of chronic liver disease in dogs.  She is also helping to spearhead efforts to develop stem cell therapy as a new approach to the treatment of acute and chronic liver disease in dogs.

Dr. Dow is a Professor in the Department of Clinical Sciences at Colorado State University.  His lab investigates immune responses in infectious diseases, cancer and allergic and autoimmune diseases.  His lab is currently studying the immune modulatory effects of mesenchymal stem cells (MSC) and the use of MSC to treat chronic kidney disease, chronic liver disease, and chronic wound infections in dogs and cats.  More recently, the lab has also begun developing induced pluripotent stem cell lines (iPSC) from canines, felines, and equines for use in regenerative medicine studies.

​Dr. Ehrhart is a Professor in the Animal Cancer Center in the Department of Clinical Sciences at Colorado State University.  Her laboratory investigates new approaches to improve bone healing for application to radiation therapy and bone cancer treatment.  Current projects include the use of local or systemic administration of mesenchymal stem cells to stimulate healing of allogeneic bone grafts following bone cancer surgery.

​Dr. Johnson is a post-DVM fellow in the Department of Microbiology, Immunology, and Pathology.  Her work is investigating the antimicrobial properties of activated mesenchymal stem cells and how they induce bacterial killing and enhance antibiotic activity in treatment of chronic infections.  She is currently conducting a clinical trial of activated MSC therapy for dogs with chronic, drug-resistant bacterial infections.

Dr. Gonzalez-Juarrero is an Associate Professor in the Department of Microbiology, Immunology, and Pathology at Colorado State University.   Her laboratory studies immune responses in TB infection, using mouse and goat models of infection.  She is currently investigating the use of siRNA inhibition of specific cytokines such as IL-10 as a novel immune therapeutic approach to treatment of chronic TB infection.

​Dr. Goh is an Assistant Professor in the Department of Clinical Sciences and she is investigating the use of mesenchymal stem cells as a new potential treatment for dogs with chronic joint injuries.  She is currently conducting a randomized clinical trial of MSC therapy in dogs with cranial cruciate rupture.

Dr. Goodrich is an Associate Professor in the Department of Clinical Sciences at Colorado State University.  Her laboratory studies new approaches to bone and joint healing in equine atheletes, including gene therapy and stem cell therapy.  Her lab is currently investigating the use of gene modified mesenchymal stem cells to suppress joint inflammation in joint disease in horses.

Dr. Guth is a Research Scientist in the Animal Cancer Center and Department of Clinical Sciences at Colorado State University.  She is currently investigating immunotherapeutic approaches to cancer treatment.  Among her projects is a studying investigating the use of cancer stem cell vaccines as a new approach to cancer immunotherapy.

Dr. Kisiday is an Associate Professor in the Department of Clinical Sciences at Colorado State University.  His laboratory studies factors that regulate the maturation of mesenchymal stem cells into functional cartilage and bone tissues.  His studies investigate the influence of substrates and specific growth factors on the mechanical properties of the regenerating mesenchymal stem cells.

​Dr. Koch is a Professor in the Department of Dermatology at the University of Colorado Denver and the Gates Center for Regenerative Medicine and Stem Cell Biology.  His laboratory focuses on understanding the genetic basis of inherited skin disorders in humans.  The Koch group also uses iPSC technology to investigate new genetic approaches to reversing the defects in genetic skin disorders. 

​Dr. Lappin is a Professor in the Department of Clinical Sciences at Colorado State University.  His laboratory studies immune responses to vaccination against respiratory viruses in cats, as well as immune responses to feline vaccines.  He also oversees a large diagnostic service for feline infectious diseases, including toxoplasmosis, Bartonella, Ehrlichia, and other infectious agents of cats.

Dr. Orton is a Professor in the Department of Clinical Sciences and the Director of the Animal Heart Center at Colorado State University.  His group studies the pathogenesis of valvular heart disease in dogs and humans.  His laboratory also uses new approaches to inhibit immune responses against xenogeneic heart valves.

​Dr. Quimby is an Assistant Professor in the Department of Clinical Sciences.  She studies the role of mesenchymal stem cell therapy for feline chronic kidney disease and the impact of therapy on intra-renal inflammation, as assessed by urinary cytokine responses.  She is also investigating the role of telomere shortening in the pathogenesis of CKD in cats.

​Dr. Regan is a post-DVM fellow in the Department of Microbiology, Immunology, and Pathology and the Animal Cancer Center.  He is currently investigating monocyte targeted therapeutics for enhancing cancer vaccine effectiveness and suppressing the growth of tumor metastases, using both mouse models and clinical studies in dogs with cancer.

Dr. Twedt is a Professor of small animal medicine in the Dept of Clinical Sciences.  He is a pioneer in the study of liver diseases of dogs and cats and has developed several new approaches to managing chronic liver disease.  Currently, he is involved in developing new stem cell therapy based approaches to treatment of chronic liver disease in dogs.

Craig Webb

Dr. Craig Webb is an Associate Professor in the Department of Clinical Sciences.  He specializes in gastrointestinal diseases of small animals and his group currently is investigating the ability of mesenchymal stem cells to suppress clinical signs in cats with inflammatory bowel disease.

Dr. Webb is a Research Scientist in the Department of Clinical Sciences.  She investigates the use of mesenchymal stem cells for suppressing airway inflammation in mouse asthma models.  In addition, she investigates the mechanisms by which mesenchymal stem cells suppress T cell responses in mice and cats.

Dr. Zabel is an Associate Professor in the Department of Microbiology, Immunology, and Pathology at Colorado State University.  His laboratory investigates the immune pathogenesis of prion diseases, specifically chronic wasting disease, and how complement proteins and white blood cells facilitate the spread of the organism.  In addition, his laboratory investigates novel immune therapeutic approaches to controlling prion infection in the brain, using mouse models of infection.

 

 CIRM Associate Members

 

​Briana is working with Dr. Johnson in the Stem Cell Laboratory to help identify factors that may regulate the ability of MSC to reverse high level bacterial resistance to antibiotics.

​Lara is currently working with Dr. Quimby in the Stem Cell Laboratory investigating the inherent differences between MSC derived from young vs old cats, and how these properties may influence their effectiveness for clinical stem cell therapy. 

​Lyndah is currently working with Dr. Dow in the Regenerative Medicine Laboratory to determine optimal methods for generation of iPSC from tissues of dogs, cats, and horses.  These cells are in turn being investigated for their ability to be differentiated into cells that can be used to regenerate organs such as the liver, kidney, and spinal cord.

​Laura is working with Dr. Ehrhart in the Laboratory of Musculoskeletal Oncology and Traumatology to investigate the effectiveness of MSC therapy for stimulation of bone healing in animals and humans undergoing massive limb allograft procedures. 

​Dr. Colbath is currently working with Dr. Goodrich in the Equine Orthopedic Research Center investigating the immunological properties of equine MSC and how these properties may influence their ability to be used for treatment of equine joint injuries. 

Jonathan is working with Dr. Dow in the Regenerative Medicine Laboratory to investigate the immunological properties of MSC and how they suppress T cell proliferation.

​Analis is working with Dr. Johnson in the Stem Cell Laboratory to study the antimicrobial properties of activated MSC and to develop the use of these cells for treatment of chronic wound infections.

​Michelina is working with Dr. Johnson to help identify the factors produced by activated MSC that exert antimicrobial activity. 

​Nikki is working with Dr. Goodrich in the Equine Orthopedic Research Center to culture equine MSC and investigate their immunological properties. 

​Molly is working with Dr. Dow in the Regenerative Medicine Laboratory to develop iPSC lines from dogs, cats, and horses and to induce the differentiation of these iPSC lines into cardiomyocytes, neurons, and endothelial cells. 

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