Professor, Department of Biomedical Sciences
Animal Reproduction and Biotechnology Laboratory
Colorado State University
DVM, Colorado State University
MS, Colorado State University
PhD, Colorado State University
I teach physiology, genetics and biotechnology to veterinary students. I also work on a project to create a comprehensive Web-based hypertext for use in teaching pathophysiology.
Research Interests -- Infectious Disease
My current interests focus on viral diseases that affect domestic and wild animals and spillover into human populations. Current projects include:
- Working to understand the pathogenesis of West Nile virus infection in domestic animals, birds and reptiles, and to develop and test vaccines to protect against that disease.
- Determining vertebrate and mosquito host competency for Japanese encephalitis, and elucidating the pathogenesis of infection in those creatures.
- Evaluating the potential role of bats in transmission of a number of viruses.
- Understanding the human-animal interface as it relates to transmission of avian influenza viruses.
- I serve as Director of the Animal Models Core of the Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Disease, and in the capacity supervise numerous trials to evaluate vaccines and therapeutics to protect against a broad range of pathogens.
For a complete list of publications, please visit: RA Bowen PubMed
Achenbach JE, Bowen RA. The effect of oseltamivir carboxylate consumption on the emergence of drug resistant H5N2 avian influenza virus in mallard ducks. Antimicrob Agents Chemother 2013; 57:2171-2181.
Baeten LA, Pappert R, Young J, Schriefer ME, Gidlewski T, Kohler D, Bowen RA. Immunological and clinical response of coyotes (Canis latrans) to experimental inoculation with Yersinia pestis. J Wildlife Dis 2013; 49:932-939.
Bosco-Lauth AM, Bowen RA. Biological significance of bats as a natural reservoir of emerging viruses. In: Viral Infections and Global Change, SK Singh (ed.), Wiley Blackwell, 2014, pp. 195-206.
Cleton NB, Bosco-Lauth A, Page MJ, Bowen RA. Age-related susceptibility to Japanese encephalitis virus in domestic ducklings and chicks. Am J Trop Med Hyg 2014; 90:242-246.
O’Shea TJ, Bowen RA, Stanley TR, Shankar V, Rupprecht CE. Variability in seroprevalence of rabies virus neutralizing antibodies and associated factors in a Colorado population of big brown bats (Eptesicus fuscus). PLoS One 2014; 9:e86261.
Soffler C, Bosco-Lauth AM, Aboellial TA, Marlof AJ, Bowen RA. Pathogenesis of percutaneous infection of goats with Burkholderia pseudomallei: clinical, pathologic, and immunologic responses in chronic melioidosis. Internat J Expt Pathol 2014; 95:101-119.
Bowen RA, Bosco-Lauth A, Syvrud K, Thomas A, Meinert TR, Ludlow DR, Cook C, Salt J, Ons E. Protection of horses from West Nile virus lineage 2 challenge following immunization with a whole, inactivated WNV lineage 1 vaccine. Vaccine 2014; 32:5455-9.
Adney DR, van Doremalen N, Brown VR, Bushmaker T, Scott D, de Wit E, Bowen RA, Munster VJ. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis 2014; 20:1999-2005.
Gaire TN, Karki S, Dhakal IP, Khanal DJ, Joshi NP, Sharma B, Bowen RA. Cross-sectional serosurvey and associated factors of bluetongue virus antibodies presence in small ruminants of Nepal. BMC Res Notes 2014; 7:e691.
Duggal NK, Bosco-Lauth A, Bowen RA, Wheeler SS, Reisen WK, Felix TA, Mann BR, Romo H, Swetnam DM, Barrett ADT, Brault AC. Evidence for co-evolution of West Nile virus and house sparrows in North America. PLoS Negl Trop Dis 2014; 8:e3262.
Langevin SA, Bowen RA, Reisen WK, Andrade CC, Ramey WN, Maharaj PD, Anishchenko M, Kenney JL, Duggal NK, Romo H, Bera AK, Sanders TA, Bosco-Lauth A, Smith JL, Kuhn R, Brault AC. Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms. PLoS One 2014; 9:e10082.
Keil S, Saakadze N, Bowen R, Newman JL, Sulaiman K, Gordy P, Marschner S, Roback J, Hillyer CD. Inactivation of viruses in platelet and plasma products using a riboflavin and UV based photochemical treatment. Transfusion 2015; DOI: 10.1111/trf.13030
Brown VR, Adney DR, Bielefeldt-Ohmann H, Gordy PW, Felix TA, Olea-Popelka FJ, Bowen RA. Pathogenesis and immune responses of Francisella tularensis strains in wild-caught cottontail rabbits. J Wildlife Dis 2015; 51:564-575.
Bosco-Lauth AM, Han S, Hartwig A, Bowen RA. Development of a hamster model for chikungunya virus infection and pathogenesis. PLoS One 2015; DOI:10.1371/journal.pone.0130150.
Brown VR, Adney DR, Olea-Popelka F, Bowen RA. Prior Inoculation with type B strains of Francisella tularensis provides partial protection against virulent type A strains in cottontail rabbits. PLoS One 2015; 10:e014073.
Root JJ, Bosco-Lauth AM, Bielefeldt-Ohmann H, Bowen RA. Experimental infection of peridomestic mammals with emergent H7N9 (A/Anhui/1/2013) influenza A virus: Implications for biosecurity and wet markets. Virology 2016; 487:242-248.
Borucki MK, Lao V, Hwang M, Gardner S, Adney D, Munster V, Bowen R, Allen JE. Middle East Respiratory syndrome coronavirus intra-host populations are characterized by numerous high frequency variants. PLoS One. 2016; 11: e0146251.
Bosco-Lauth, AM, Nemeth NM, Kohler DK, Bowen RA. Viremia in North American mammals and birds following experimental infection with chikungunya viruses. Am J Trop Med Hyg 2016; 94:504-506.