Professor, Department of Biomedical Sciences
Animal Reproduction and Biotechnology Laboratory
Colorado State University
DVM, Colorado State University
MS, Colorado State University
PhD, Colorado State University
I teach physiology, genetics and biotechnology to undergraduate and veterinary students. I also work on a project to create a comprehensive Web-based hypertext for use in teaching pathophysiology.
Research Interests -- Infectious Disease
My current interests focus on viral diseases that affect domestic and wild animals and spillover into human populations. Current projects include:
- Working to understand the pathogenesis of West Nile virus infection in domestic animals, birds and reptiles, and to develop and test vaccines to protect against that disease.
- Determining vertebrate and mosquito host competency for Japanese encephalitis, and elucidating the pathogenesis of infection in those creatures.
- Evaluating the potential role of bats in transmission of a number of viruses.
- Understanding the human-animal interface as it relates to transmission of avian influenza viruses.
- I serve as Director of the Animal Models Core of the Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Disease, and in the capacity supervise numerous trials to evaluate vaccines and therapeutics to protect against a broad range of pathogens.
For a complete list of publications, please visit: RA Bowen PubMed
Bunning ML, Bowen RA, Cropp CB, Sullivan GB, Davis BS, Komar N, Godsey M, Baker D, Hettler DL, Holmes DA, Biggerstaff GJ, Mitchell CJ. 2002. Experimental infection of horses with West Nile virus. Emerg Infect Dis 8:380-386.
Austgen LE, Bowen RA, Bunning ML, Davis BS, Mitchell CJ, Chang GJ. 2004. Experimental infection of cats and dogs with West Nile virus. Emerg Infect Dis. 10:82-86.
Weaver SC, Anishchenko M, Bowen R, Brault AC, Estrada-Franco JG, Fernandez Z, Greene I, Ortiz D, Paessler S, Powers AM. 2004. Genetic determinants of Venezuelan equine encephalitis emergence. Arch Virol 18:43-64.
Shankar V, Bowen RA, Davis A, Rupprecht CE, O'Shea TJ. 2004. Rabies in a captive colony of Big Brown bats (Eptesicus fuscus). J Wildlife Dis 40:403-413.
Siger L, Bowen R, Karaca K, Murray M, Gordy P, Loosmore S, Audonnet J, Nordgren R, Minke JM. 2004. Assessment of the efficacy of a single dose of a recombinant vaccine against West Nile Virus in response to natural challenge with West Nile virus-infected mosquitoes in horses. Am J Vet Res 65:1459-1462.
Klenk K, Snow J, Morgan K, Bowen R, Stephens M, Foster F, Gordy P, Beckett S, Komar N, Gubler D, Bunning M. 2004. Juvenile American alligators (Alligator mississippiensis) as amplifiers of West Nile virus. Emerg Infect Dis 10:2150-2155.
Brault AC, Langevin SA, Bowen RA, Panella NA, Biggerstaff BJ, Miller BR, Komar N. 2004. West Nile viral strains exhibit differential virulence for American crows (Corvus brachyrhynchos). Emerg Infect Dis 10:2161-2168.
Teehee ML, Bunning ML, Stevens S, Bowen RA. 2005. Experimental infection of pigs with West Nile virus. Arch Virol 150:1249-1256.
Davis A, Bunning M, Gordy P, Panella N, Blitvich B, Bowen R. 2005. Experimental and natural infection of North American bats with West Nile virus. Am J Trop Med Hyg 73:467-469.
Bowen RA, Rouge MM, Siger L, Minke JM, Nordgren R, Karaca K, Johnson J. 2006. Pathogenesis of West Nile virus infection in dogs treated with glucocorticoids. Am J Trop Med Hyg 74:670-673.
Anishchenko M, Bowen RA, Paessler S, Austgen L, Greene IP, Weaver SC. 2006. Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation. Proc Natl Acad Sci USA 103:4994-4999.
Nemeth N, Gould D, Bowen R, Komar N. 2006. West Nile virus infection in five raptor species. J Wildlife Dis 42:1-13.
Nemeth NN, Bowen RA. 2007. Dynamics of passive immunity to West Nile virus in domestic chickens (Gallus gallus domesticus). Am J Trop Med Hyg 76:310-317.
Ellison LE, O'Shea TJ, Neubaum DJ, Bowen RA. 2007. Factors influencing movement of big brown bats (Eptesicus fuscus) in buildings. Ecol Applications 17:620-627.
Fine DL, Roberts BA, Teehee ML, Terpening SJ, Kelly CLH, Raetz JL, Baker DC, Powers AM, Bowen RA. 2007. Venezuelan equine encephalitis virus vaccine candidate (V3526) safety, immunogenicity, and efficacy in horses. Vaccine 25:1868-1876.
Bowen RA, Nemeth N. 2007. Experimental infections with West Nile virus. Curr Opinion Infect Dis 20:293-297.
Nemeth N, Oesterle P, Bowen R. 2008. Passive immunity to West Nile virus provides limited protection in a common passerine species. Am J Trop Med Hyg 79: 283-290.
Nemeth NA, Bosco-Lauth AM, Bowen RA. 2009. Cross protection between West Nile and Japanese Encephalitis viruses in red-winged blackbirds (Agelaius phoeniceus). Avian Dis 53:421-425.
O'Shea TJ, Ellison LE, Neubaum DJ, Neubaum MA, Reynolds CA, Bowen RA. 2010. Recruitment in a Colorado population of big brown bats: breeding probabilities, litter size, and first-year survival. J Mammalogy 91:418–428.
Nemeth NM, Bosco-Lauth AM, Sciulli RH, Gose RB, Nagata MT, Bowen RA. 2010. Serosurveillance for Japanese encephalitis and West Nile viruses in resident birds in Hawaii. J Wildlife Dis 46:659–664.
Cogswell-Hawkinson A, Bowen R, James S, Gardiner D, Callisher C, Adams R, Schountz T. Tacaribe Virus Causes Fatal Infection of An Ostensible Host, the Jamaican Fruit Bat. J Virol 2012; 86:5791-5799.
Nemeth N, Bosco-Lauth A, Oesterle P, Kohler D, Bowen R. North American birds as potential amplifying hosts for Japanese encephalitis virus. Am J Trop Med Hyg 2012; 87:760-767.
Soffler C, Bosco-Lauth AM, Aboellail TA, Marolf AJ, Bowen RA. Development and characterization of a caprine aerosol infection model of melioidosis. PLoS One 2012; 7:e43207.
Clegg CH, Roque R, Van Hoeven N, Perrone L, Baldwin SL, Rininger JA, Bowen RA, Reed SG. Adjuvant solution for pandemic influenza vaccine production. Proc Natl Acad Sci U.S.A 2012; 109:17585-90.
Bowen RA, O’Shea TJ, Shankar V, Neubaum MA, Neubaum DJ, Rupprecht CE. Prevalence of neutralizing antibodies to rabies virus in serum of seven species of insectivorous bats from Colorado and New Mexico, USA. J Wildlife Dis 2013; 49:367-374.
Ndaluka C, Bowen RA. Responses of mice to inoculation of low doses of a bat rabies virus variant. Arch Virol 2013; 158:1355-1359.
Jia Q, Bowen R, Sahakian J, Dillon BJ, Horwitz MA. A heterologous prime-boost vaccination strategy comprising Francisella tularensis Live Vaccine Strain capB mutant and recombinant attenuated Listeria monocytogenes expressing F. tularensis IglC induces potent protective immunity in mice against virulent F. tularensis aerosol challenge. Infect Immun 2013; 81:1550-1561.
Achenbach JE, Bowen RA. The effect of oseltamivir carboxylate consumption on the emergence of drug resistant H5N2 avian influenza virus in mallard ducks. Antimicrob Agents Chemother 2013; 57:2171-2181.
Hayman DTS, Bowen RA, Cryan PM, McCracken GF, O’Shea TJ, Peel AJ, Gilbert A, Webb CT, Wood JLN. Ecology of zoonotic infectious diseases in bats: Current knowledge and future directions. Zoonoses Pub Health 2013; 60:2-21.
Drolet BS, Reister LM, RIgg TD, Nol P, Podell, BK, Mecham JO, VerCauteren KC, van Rijin PA, Wilson WC, Bowen RA. Experimental infection of white-tailed deer (Odocoileus virginianus) with Northern European bluetongue virus serotype 8. Vet Micro 2013; 166:347-355.
Baeten LA, Pappert R, Young J, Schriefer ME, Gidlewski T, Kohler D, Bowen RA. Immunological and clinical response of coyotes (Canis latrans) to experimental inoculation with Yersinia pestis. J Wildlife Dis 2013; 49:932-939.
Angenvoort A, Brault AC, Bowen RA, Groschup MH. West Nile viral infections in equids. Vet Microbiol 2013; 167:168-180.
Cleton NB, Bosco-Lauth A, Page MJ, Bowen RA. Age-related susceptibility to Japanese encephalitis virus in domestic ducklings and chicks. Am J Trop Med Hyg 2014; 90:242-246.
O’Shea TJ, Bowen RA, Stanley TR, Shankar V, Rupprecht CE. Variability in Seroprevalence of Rabies Virus Neutralizing Antibodies and Associated Factors in a Colorado Population of Big Brown Bats (Eptesicus fuscus). PLoS One 2014; 9:e86261.
Soffler C, Bosco-Lauth AM, Aboellial TA, Marlof AJ, Bowen RA. Pathogenesis of percutaneous infection of goats with Burkholderia pseudomallei: clinical, pathologic, and immunologic responses in chronic melioidosis. Internat J Expt Pathol 2014; 95:101-119.