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Office: W146 ARBL Building, Foothills Campus
Phone: 970-491-1769
Fax: 970-491-3557
Email: D_N_Rao.Veeramachaneni@ColoState.edu

D. N. Rao Veeramachaneni, BVSc, MScVet, PhD

​Professor, Department of Biomedical Sciences
Animal Reproduction & Biotechnology Laboratory
Colorado State University

Education


PhD, University of Illinois at Urbana-Champaign
MScVet, AP Agricultural University, India
BVSc, AP Agricultural University

Teaching Activities


I teach BMS 460-Essentials of Pathophysiology and BMS 461-Pathophysiology Perspectives, a capstone course series in Biomedical Sciences Undergraduate Major curriculum. I also teach in the areas of andrology and reproductive toxicology in several courses at graduate level.

 

Research Interests - Andrology and Reproductive Toxicology


I have been studying the male reproductive system in a variety of animal species with the aim of broadly integrating functional aspects of different components of the system in health and disease. There has been a concern about declining seminal quality and reproductive health in men worldwide. In an attempt to understand if this problem is really idiopathic, as male infertility often is labeled, or a consequence of exposure to environmental pollutants, my current research is focused on investigating long-term sequelae of exposure in utero and/or during infancy to ubiquitous chemical contaminants. Of particular interest is pathogenesis of carcinoma in situ in the testis.

For additional information, consult the page on Reproductive Toxicology.

Service Activities


Applying this rather broad line of scientific pursuit, I also have been providing clinical and research support services. These services include evaluation of male reproductive tissues and semen for morphology and ultrastructural cytopathology enabling diagnosis of disease conditions and/or assessment of potential fertility. A wide spectrum of species including domesticated (cattle, horses, dogs, and cats) and wild animals (cheetah, deer and eland) have been referred from around the world. In some cases, knowledge acquired from laboratory research enabled association of possible etiological/environmental factors to the condition manifested.

For additional information on services offered for sperm morphology and use of semen as biopsy material, consult the page on Sperm Morphology Services.

Representative Publications


For a complete list of publications, please visit: DN Veeramachaneni PubMed

Veeramachaneni DNR. 2017. Utility of testing sperm DNA fragmentation: an all-in-one diagnostic tool to address a multi-pronged clinical problem. Translational Andrology and Urology  6 (Suppl 4):S462-S464.

Reddivari L, Veeramachaneni DNR, Walters WA, Lozupone C, Palmer J, Hewage MKK, Bhatnagar R, Amir A, Kennett MJ, Knight R, Vanamala JKP. 2017. Perinatal Bisphenol A Exposure Induces Chronic Inflammation in Rabbit Offspring via Modulation of Gut Bacteria and Their Metabolites. mSystems 2(5). pii: e00093-17. Circulating miRNAs as Potential Alternative Cell Signaling Associated with Maternal Recognition of Pregnancy in the Mare.
 
Klohonatz KM, Cameron AD, Hergenreder JR, da Silveira JC, Belk AD, Veeramachaneni DN, Bouma GJ, Bruemmer JE. 2016. Biol Reprod. 2016. Circulating miRNAs as Potential Alternative Cell Signaling Associated with Maternal Recognition of Pregnancy in the Mare.  95(6):124.
 
Henkes LE, Pru JK, Ashley RL, Anthony RV, Veeramachaneni DN, Gates KC, Hansen TR. 2015. Embryo mortality in Isg15-/- mice is exacerbated by environmental stress. Biol Reprod 92(2):36.
 
Veeramachaneni DNR, Klinefelter GR.2014. Phthalate-induced pathology in the foetal testis involves more than decreased testosterone production. Reproduction 147:435-442.

Klinefelter GR, Laskey JW, Winnik WM, Suarez JD, Roberts NL, Strader LF, Riffle BW, Veeramachaneni -DNR. 2012. Novel molecular targets associated with testicular dysgenesis induced by gestational exposure to diethylhexyl phthalate in the rat: A role for estradiol? Reproduction 144: 747-761.

Veeramachaneni DNR. 2012. Ultrastructural evaluation of semen to assess effects of exposure to toxicants. Toxicol Pathol 40:382-390.

Seachrist DD, Johnson E, Magee C, Clay CM, Graham JK, Veeramachaneni DNR, Keri RA. 2012. Overexpression of follistatin in the mouse epididymis disrupts fluid resorption and sperm transit in testicular excurrent ducts. Biol Reprod 87:41.

da Silveira JC, Veeramachaneni DNR, Winger QA, Carnevale EM, Bouma GJ. 2012. Cell-secreted vesicles in equine ovarian follicular fluid contain miRNAs and proteins: a possible new form of cell communication within the ovarian follicle. Biol Reprod 86:71.

Bush JM, Gardiner DW, Palmer JS, Rajpert-De Meyts E, Veeramachaneni DNR. 2011. Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. Int J Androl 34 (4 Pt 2):e288-e295.

Bornman MS, Barnhoorn IEJ, Dreyer L, de Jager C, Veeramachaneni DNR. 2010. Testicular microlithiasis and neoplastic lesions in wild eland (Tragelaphus oryx): Possible effects of exposure to environmental pollutants? Environ Res 110:327-333.

Wadas BC, Hartshorn CA, Aurand ER, Palmer JS, Roselli CE, Noel ML, Gore AC, Veeramachaneni DNR, Tobet SA. 2010. Prenatal exposure to vinclozolin disrupts selective aspects of the gonadotropin-releasing hormone neuronal system of the rabbit. J Neuroendocrinol 22:518-526.

Veeramachaneni DNR. 2008. Impact of environmental pollutants on the male: Effects on germ cell differentiation. Anim Reprod Sci 105:144-157.

Ljungvall K, Veeramachaneni DNR, Hou M, Hulten F, Magnusson U. 2008. Morphology and morphometry of the reproductive organs in prepubertal and postpubertal male pigs exposed to di(2ethylhexyl) phthalate before puberty: Precocious development of bulbourethral glands. Theriogenology 70:984-991.

Veeramachaneni DNR, Palmer JS, Klinefelter GR. 2007. Chronic exposure to low levels of dibromoacetic acid, a water disinfection by-product, adversely affects reproductive function in male rabbits. J Androl 28:565-577.

Veeramachaneni DNR, Palmer JS, Amann RP, Pau K-YF. 2007. Sequelae in male rabbits following developmental exposure to p,p'-DDT or a mixture of p,p'-DDT and vinclozolin: cryptorchidism, germ cell atypia, and sexual dysfunction. Reprod Toxicol 23:353-365.

Amann RP, Veeramachaneni DNR. 2007. Cryptorchidism in common eutherian mammals. Reproduction:133:541-561.

Meyer KJ, Reif JS, Veeramachaneni DNR, Luben TJ, Mosley BS, and Nuckols JR. 2006. Agricultural pesticide use and hypospadias in Eastern Arkansas. Environ Health Perspect 114:1589-1595.

Bisenius ES, Veeramachaneni DNR, Sammonds GE, Tobet S. 2006. Sex differences and the development of the rabbit brain: Effects of vinclozolin. Biol Reprod:75:469-476.

Veeramachaneni DNR, Palmer JS, Amann RP, Kane CM, Higuchi TT, Pau K-YF. 2006. Disruption of sexual function, FSH secretion, and spermiogenesis in rabbits following developmental exposure to vinclozolin, a fungicide. Reproduction 131:805-816.

Veeramachaneni DNR, Amann RP, Jacobson JP. 2006. Testis-antler dysgenesis in Sitka Black-tailed deer on Kodiak Island, Alaska: Sequela of environmental endocrine disruption? Environ Health Perspect 114 (Suppl 1):51-59.

Veeramachaneni DNR. 2006. Germ cell atypia in undescended testes hinges on the aetiology of cryptorchidism but not the abdominal location per se. Int J Androl 29:235-240.

Weber NM, Sawyer HR, Legare ME, Veeramachaneni DNR. 2006. Sub-chronic exposure to dibromoacetic acid, a water disinfection by-product, does not affect gametogenic potential in mice. Toxicol Sci 89:325-330.

Lee SK, Owens GA, Veeramachaneni DNR. 2005. Exposure to low concentrations of di-n-butyl phthalate during embryogenesis reduces the survivability and impairs development of Xenopus laevis frogs. J Toxicol Environ Health Part A 68:763-772.

Lee SK, Veeramachaneni DNR. 2005. Sub-chronic exposures to low concentrations of di-n-butyl phthalate disrupts spermatogenesis in Xenopus laevis frogs. Toxicol Sci 84:394-407.

Weber NM, Higuchi TT, Tessari JD, Veeramachaneni DNR. 2004. Evaluation of effects of water disinfection by-products, bromochloroacetic and dibromoacetic acids, on frog embryogenesis. J Toxicol Environ Health A 67:929-939.

Bodensteiner KJ, Sawyer HR, Moeller CL, Kane CM, Pau K-YF, Klinefelter GR, Veeramachaneni DNR. 2004. Chronic exposure to dibromoacetic acid, a water disinfection by-product, diminishes primordial follicle populations in the rabbit. Toxicol Sci 80:83-91.

Higuchi TT, Palmer JS, Gray LE Jr, Veeramachaneni DNR. 2003. Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or post-pubertal exposure. Toxicol Sci 72:301-313.

Lange IG, Daxenberger A, Meyer HHD, Rajpert-De Meyts E, Skakkebaek NE, Veeramachaneni DNR. 2002. Quantitative assessment of fetal exposure to trenbolone acetate, zeranol, and melengestrol acetate following maternal dosing in rabbits. Xenobiotica 32:641-651.

Veeramachaneni DNR, Palmer JS, Amann RP. 2001. Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water. Human Reprod 16:979-987.

Gray LE Jr, Ostby J, Furr J, Wolf CJ, Lambright C, Parks L, Veeramachaneni DNR, Wilson V, Price M, Hotchkiss A, Orlando E, Guillette L. 2001. Effects of environmental antiandrogens in experimental animals. Human Reprod Update 7:248-264.

Roberts D, Veeramachaneni DNR, Schlaff WD, Awoniyi CA. 2000. Effects of chronic dietary exposure to genistein, a phytoestrogen, during various stages of development on reproductive hormones and spermatogenesis in rats. Endocrine 13:281-286.

Gray LE Jr, Ostby J, Furr J, Price M, Veeramachaneni DNR, Parks L. 2000. Perinatal exposure to the phthalates DEHP, BBP and DINP, but not DEP, DMP or DOTP alters sexual differentiation of the male rat. Tox Sci 58:350-365.

Veeramachaneni DNR. 2000. Deteriorating trends in male reproduction: Idiopathic or Environmental? Anim Reprod Sci 60-61:121-130. (Plenary lecture, XIV International Congress on Animal Reproduction, Stockholm)

Book Chapters

Klinefelter GR, Veeramachaneni DNR. 2014. Assessment of Male reproductive Toxicity. Chapter 34.  In: Hayes’ Principles and Methods of Toxicology, 6th Edition (Ed Hayes AW), Philadelphia: Taylor and Francis, pp 1596-1629.

Veeramachaneni DNR. 2011. Spermatozoal Morphology. Chapter 126 In: Equine Reproduction, 2nd Edition (Ed McKinnon AO, Squires EL, Vaala WE, Varner DD), Oxford: Wiley-Blackwell, pp 1297-1307.

Loveland K, Rajpert-De Meyts E, Veeramachaneni DNR. 2010. Testicular Cancer. Chapter 11.12 In: Comprehensive Toxicology, 2nd Edition (Ed Charlene A. McQueen), Oxford: Elsevier, pp 247-263.