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Melinda Frye

​Associate Dean of Veterinary Academic and Student Affairs

Colle​ge of Veterinary Medicine and Biomedical Sciences

Office: W102 Anatomy/Zoology
Phone: 970-491-2009
Fax: 970-491-2250

Melinda A. Frye, D.V.M., Ph.D., DACVIM


Ph.D., Colorado State University
M.S., Colorado State University
D.V.M., Colorado State University
B.S.N., Linfield College
Diplomate American College of Veterinary Internal Medicine

Teaching Interests


  • Cardiovascular and pulmonary physiology and pathophysiology
  • Comparative physiology
  • Application of physiologic principles to human and veterinary medicine


  • VM 610-611 Foundations of Veterinary Medicine I/II
  • VM 618 Veterinary Physiology and Histology
  • VM 618 Functional Anatomy
  • VM 7222 Veterinary Pharmacology
  • BMS 501 Mammalian Physiology II


  • Incorporation of demonstrations and clinical footage into the classroom environment
  • Web-based resources and learning
  • Review of current literature
  • Provision of learning opportunities requiring critical thinking and practical application of principles learned

Representative Publications

Frye MA, Johnson JS, Traub-Dargatz J, Savage CJ, Fettman MJ, Gould DH. 2001. Putative uremic encephalopathy in horses: 5 cases (1978-1998). J Am Vet Med Assoc 218:560-566.

Frye MA, Selders CG, Mama KR, Wagner AE, Bright JM. 2002. Use of biphasic electrical cardioversion for treatment of idiopathic atrial fibrillation in two horses. J Am Vet Med Assoc 220:1039-1045.

Frye MA, Bright JM, Dargatz DA, Fettman MJ, Frisbie DD, Baker DC, Traub-Dargatz JL. 2003. A comparison of dobutamine infusion to exercise as a cardiac stress test in healthy horses. J Vet Internal Med 17:58-64.

Frye MA. 2006. Pathophysiology, diagnosis, and management of urinary tract infection in horses. Vet Clin Equine 22:497-517.

Lawler JB, Frye MA, Bera MM, Ehrhart EJ, Bright JM. 2008. Third-degree atrioventricular block in a horse secondary to rattlesnake envenomation. J Vet Intern Med 22:486-90.

Frye M, McMurtry I, Orton EC, Fagan K. 2009. Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism. Comp Med 59:1-7.

Gentile C, Frye M, Pagliassotti M. 2010. Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease. Antioxid Redox Signal 15:505-521.

Gentile CL, Frye MA, Pagliassotti MJ. 2010. Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. Biofactors 37:8-16.

Jeckel KM, Miller KE, Chicco AJ, Chapman PL, Mulligan CM, Falcone PH, Miller ML, Pagliassotti MJ, Frye MA. 2011. The role of dietary fatty acids in predicting myocardial structure in fat-fed rats. Lipids Health Dis 10:92.

Frye MA, Cook V. Cardiovascular system. In: Equine Emergency Medicine and Critical Care, Southwood LL and Wilkins PA (eds). Manson Publishing, Middlesex.

Mehlman E, Bright JM, Jeckel K, Porsche C, Veeramachaneni DNR, Frye M. Echocardiographic evidence of left ventricular hypertrophy in obese dogs. JVIM 2013; 27:62-68.

Nivala AM, Reese L, Hemenway E, Frye M, Gentile CL, Pagliassotti MJ. Fatty acid-mediated endoplasmic reticulum stress in vivo: Differential response to the infusion of soybean or lard oil in rats. Metabolism 2013; 62:753-60. PMID: 23312405.

Wang D, Wei Y, Frye M, Gentile CL, Pagliassotti MJ. Saturated fatty acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10. J Nutr Metab 2013; 2013:514206. PMID: 23691291.

Le CH, Mulligan CM, Routh MA, Bouma GJ, Frye MA, Jeckel KM, Sparagna GC, Lynch JM, Moore RL, McCune SA, Bristow M, Zarini S, Murphy RC, Chicco AJ. Delta-6-desaturase links PUFA metabolism with phospholipid remodeling and disease progression in heart failure. Circ Heart Fail 2013; Nov 27. PMID: 24284026

Otis JS, Niccoli S, Hawdon N, Sarvas JL, Frye MA, Chicco AJ, Lees SJ. Pro-inflammatory mediation of myoblast proliferation. PLoS ONE 2014; 9:e92363.