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 Dr. Yumei Feng (right) with Research Scientist Wencheng Li in the lab.

The Feng Laboratory

 

 Feng Lab Information

 
 

 Contact the Lab

 

Phone: (970) 491-3729

Email: yumei.feng@colostate.edu

Location: W210 Anatomy/Zoology

Mailing Address:
1617 Campus Delivery
Fort Collins, CO 80523
The focus of our laboratory is to understand the neural mechanisms of hypertension and other cardiovascular diseases. Our current interest is focused on the physiological and pathophysiological role of the (pro)renin receptor (PRR) and prorenin as a novel pathway for brain renin-angiotensin system. Briefly, we are interested in dissecting the importance of PRR in neurons and glial cells in mediating angiotensin II formation, and the neural circuits involved in hypertension with special focus on the SFO and PVN. To achieve our goal, we have developed a PRR conditional knockout mouse (Cre-Loxp strategy) model and a neuron-targeted human PRR transgenic mouse model. We have also developed adeno-associated virus coding for PRR or PRR-shRNA to specifically target brain nuclei. These powerful tools combined with our expertise in continuous BP recordings (telemetry), analysis of autonomic function, and metabolic cage study allow us to dissect the neural mechanisms and signaling of brain PRR in cardiovascular diseases.

 

 Recent News

 

In August, the Department of Biomedical Sciences welcomed Dr. Yumei Feng, an assistant professor specializing in neural mechanisms of cardiovascular physiology.