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 Images of sperm from animals that were exposed to environmental pollutants.

Reproductive Toxicology

The Veeramachaneni laboratory has spearheaded investigations on the developmental and long-term reproductive consequences of perinatal exposure to ubiquitous pollutants using mammalian and amphibian models. 

Several recent reports indicate deteriorating trends in optimal reproduction in the human male, particularly in the industrialized world. Common pollutants having hormone-mimicking capabilities have been implicated in these phenomena. The compounds being studied include:

  • anti-androgen pesticides (DDT and its metabolites; vinclozolin)
  • water disinfection by-products (dibromoacetic acid, bromochloroacetic acid)
  • detergents (alkyl phenols)
  • plasticizers (phthalates)

Two aspects of male reproductive function have been studied: sexual function and efficiency and quality of spermatogenesis.

Invited Presentations

2014: In search of a link between dwindling male and endocrine-disrupting chemicals. Keynote Lecture, Rocky Mountain Reproductive Sciences Symposium, Fort Collins, CO

2013: Molecular targets associated with gonadal dysgenesis induced by intra-uterine exposure to DEHP. 7th Copenhagen Workshop on Endocrine Disrupters: Human Environment, Lifestyle, and Genes in Endocrine Disruption, Copenhagen, Denmark

2012: Organized and chaired an international symposium on Reproductive Toxicology and Environment. 17th International Congress on Animal Reproduction, Vancouver, Canada

2011: Ultrastructural Evaluation of Semen to Assess Effects of Exposure to Environmental Toxicants. Annual Symposium: Ultrastructural Analysis and Toxicologic Pathology, Society of Toxicologic Pathology, Denver, CO

2010: Animal Models for Testicular Germ Cell Tumours. VII Copenhagen Workshop on CIS Testis and Germ Cell Cancer: From Basic Science to Improved Diagnosis and Management, Copenhagen, Denmark

Animal Models for Testicular Cancer. Symposium: Life in the Womb—Fetal Determinants of Men’s Reproductive Health. American Society of Andrology, Houston, TX

2006: Overview of Phthalates. Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden

Toxicology as a Tool to Unravel “Idiopathic” Reproductive Failure in the Male. Dept of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden

2005: Testicular tumors and chemical-induced germ cell atypia in animals. Copenhagen Workshop on Environment, Reproductive Health and Fertility, Rigshospitalet, Copenhagen, Denmark

2004: Effects of Endocrine Disrupting Chemicals on Reproductive Behavior. Ecological Relevance of Chemically-Induced Endocrine Disruption in Wildlife, University of Exeter, Exeter, UK

Impact of Phthalates on the Male. USEPA Human Health Symposium, Philadelphia, PA

Effects of Drugs and Toxins on Spermatogenesis. The Bluegrass Equine Reproduction Symposium, Lexington, KY

Insidious Effects of "Innocuous" Chemicals in the Male. Center for Reproductive Biology, Washington State University, Pullman, WA

2003: Relevant Models, Vulnerable Windows and Late Effects in Mammalian Reproductive Toxicology. European Environmental Agency, Copenhagen, Denmark

2002: Effects of Early Developmental Exposure to Endocrine Disrupting Chemicals on Reproductive Function in the Adult Male: Rabbit Model. USEPA Endocrine Disruptors Workshop, Research Triangle Park, NC

The Dwindling Male: Idiopathic or Environmental? Dept of Farm Animal Health and Resource Management, North Carolina State University, Raleigh, NC

The Rabbit May Represent a Better Animal Model for Determining Reproductive Risk Associated with Disinfection By-products. Workshop: Is There a Reproductive Risk Associated with Exposure to Disinfection By-products of Drinking Water? 41st Annual Meeting of Society of Toxicology, Nashville, TN

2001: Abdominal Location Alone Does Not Cause Carcinoma in situ in Undescended Testes. Dept of Growth and Reproduction, University of Copenhagen Hospital, Denmark

2000: Deteriorating Trends in Male Reproduction: Idiopathic or Environmental? Plenary Lecture, 14th International Congress on Animal Reproduction, Stockholm, Sweden

Long-term Effects on Male Reproduction of Early Exposure to Chemicals in Drinking Water. International Workshop on Hormones and Endocrine Disruptors in Food and Water: Possible Impact on Human Health, Copenhagen, Denmark

1999:  Deteriorating Trends in Male Reproductive Function. Grand Rounds, Dept of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX

Common Chemical Contaminants as Endocrine Disruptors: Fact or Fiction? NIEHS Toxicology Training Program and Sealy Center for Molecular Science,University of Texas Medical Branch, Galveston, TX

1997: Carcinoma in situ in the Testes of Domestic and Laboratory Animals. IV Copenhagen Workshop on Carcinoma in situ and Cancer of the Testis: Molecular and Endocrine Aspects, Copenhagen, Denmark

1995: Infantile Exposure to a Chemical Mixture in Drinking Water: Reproductive Sequelae in the Adult Male. Health Effects Research Laboratory-USEPA, Research Triangle Park, NC



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